5MYK

Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with murine Abeta-pE3-18PEGb

Summary for 5MYK

• Entry DOI: 10.2210/pdb5myk/pdb
• Descriptor: Fab c#17 light chain, Fab c#17 heavy chain, Amyloid beta A4 protein, ... (4 entities in total)
• Functional Keywords: alzheimer's disease, pyroglutamate abeta, monoclonal antibody, fibrillation, immune system
• Biological source: Mus musculus (House mouse); More
• Total number of polymer chains: 3
• Total formula weight: 50600.25

Authors

Parthier, C.,Piechotta, A.,Stubbs, M.T. (deposition date: 2017-01-26, release date: 2017-06-28, Last modification date: 2024-01-17)

• Primary citation: Piechotta, A.,Parthier, C.,Kleinschmidt, M.,Gnoth, K.,Pillot, T.,Lues, I.,Demuth, H.U.,Schilling, S.,Rahfeld, J.U.,Stubbs, M.T.; Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.; J. Biol. Chem., 292:12713-12724, 2017; PubMed: 28623233; DOI: 10.1074/jbc.M117.777839

Experimental method

X-RAY DIFFRACTION (1.6 Å)