3BAE

Crystal structure of Fab WO2 bound to the N terminal domain of Amyloid beta peptide (1-28)

Summary for 3BAE

• Entry DOI: 10.2210/pdb3bae/pdb
• Descriptor: WO2 IgG2a Fab fragment Light Chain Kappa, WO2 IgG2a Fab fragment Heavy Chain, Amyloid Beta Peptide, ... (4 entities in total)
• Functional Keywords: abeta, amyloid beta peptide, fab, wo2, alzheimer's disease, immunotherapies, app, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 3
• Total formula weight: 52246.20

Authors

Miles, L.A.,Wun, K.S.,Crespi, G.A.,Parker, M.W. (deposition date: 2007-11-07, release date: 2008-04-15, Last modification date: 2023-11-01)

• Primary citation: Miles, L.A.,Wun, K.S.,Crespi, G.A.,Fodero-Tavoletti, M.T.,Galatis, D.,Bagley, C.J.,Beyreuther, K.,Masters, C.L.,Cappai, R.,McKinstry, W.J.,Barnham, K.J.,Parker, M.W.; Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.; J.Mol.Biol., 377:181-192, 2008; PubMed: 18237744; DOI: 10.1016/j.jmb.2007.12.036

Experimental method

X-RAY DIFFRACTION (1.593 Å)