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5MYX

Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18

Summary for 5MYX
Entry DOI10.2210/pdb5myx/pdb
DescriptorFab c#24 light chain, Fab c#24 heavy chain, Pyroglutamate-Abeta pE3-18, ... (4 entities in total)
Functional Keywordsalzheimer's disease, pyroglutamate abeta, monoclonal antibody, fibrillation, immune system
Biological sourceMus musculus
More
Total number of polymer chains6
Total formula weight105330.25
Authors
Parthier, C.,Piechotta, A.,Stubbs, M.T. (deposition date: 2017-01-30, release date: 2017-06-28, Last modification date: 2024-01-17)
Primary citationPiechotta, A.,Parthier, C.,Kleinschmidt, M.,Gnoth, K.,Pillot, T.,Lues, I.,Demuth, H.U.,Schilling, S.,Rahfeld, J.U.,Stubbs, M.T.
Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292:12713-12724, 2017
Cited by
PubMed: 28623233
DOI: 10.1074/jbc.M117.777839
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.492 Å)
Structure validation

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