8BG0
Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40
Summary for 8BG0
Entry DOI | 10.2210/pdb8bg0/pdb |
EMDB information | 16023 |
Descriptor | Amyloid-beta precursor protein (2 entities in total) |
Functional Keywords | amyloid, amyloid-beta, arctic mutation, app, filaments, e22g, e693g, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 17343.41 |
Authors | Yang, Y.,Zhang, W.J.,Murzin, A.G.,Schweighauser, M.,Huang, M.,Lovestam, S.K.A.,Peak-Chew, S.Y.,Macdonald, J.,Lavenir, I.,Ghetti, B.,Graff, C.,Kumar, A.,Nordber, A.,Goedert, M.,Scheres, S.H.W. (deposition date: 2022-10-27, release date: 2023-01-18, Last modification date: 2023-02-22) |
Primary citation | Yang, Y.,Zhang, W.,Murzin, A.G.,Schweighauser, M.,Huang, M.,Lovestam, S.,Peak-Chew, S.Y.,Saito, T.,Saido, T.C.,Macdonald, J.,Lavenir, I.,Ghetti, B.,Graff, C.,Kumar, A.,Nordberg, A.,Goedert, M.,Scheres, S.H.W. Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145:325-333, 2023 Cited by PubMed: 36611124DOI: 10.1007/s00401-022-02533-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (1.9 Å) |
Structure validation
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