4MVL

Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40

Summary for 4MVL

Entry DOI	10.2210/pdb4mvl/pdb
Related	4MVI 4MVK
Descriptor	Neutrophil gelatinase-associated lipocalin, Beta-amyloid protein 40 (3 entities in total)
Functional Keywords	beta-barrel, engineered lipocalin, binding protein, protein binding-protein fibril complex, protein binding/protein fibril
Biological source	Homo sapiens (human) More
Cellular location	Secreted : P80188 Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains	8
Total formula weight	103140.38
Authors	Eichinger, A.,Skerra, A. (deposition date: 2013-09-24, release date: 2015-08-12, Last modification date: 2023-09-20)
Primary citation	Rauth, S.,Hinz, D.,Borger, M.,Uhrig, M.,Mayhaus, M.,Riemenschneider, M.,Skerra, A. High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide. Biochem.J., 473:1563-1578, 2016 Cited by PubMed: 27029347 DOI: 10.1042/BCJ20160114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation