4MVL
Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Neutrophil gelatinase-associated lipocalin | polymer | 188 | 21449.2 | 4 | UniProt (P80188) Pfam (PF00061) In PDB | Homo sapiens (human) | NGAL, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25 |
2 | E, F, G, H | Beta-amyloid protein 40 | polymer | 40 | 4335.9 | 4 | UniProt (P05067) Pfam (PF03494) In PDB | Homo sapiens | Beta-APP40 |
3 | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 178 (UniProt: P80188)
PDB | External Database | Details |
---|---|---|
His 28 | Gln 48 | engineered mutation |
Ala 36 | Leu 56 | engineered mutation |
Val 40 | Ala 60 | engineered mutation |
Leu 41 | Ile 61 | engineered mutation |
Leu 49 | Gln 69 | engineered mutation |
Gly 70 | Leu 90 | engineered mutation |
Asp 72 | Arg 92 | engineered mutation |
Asp 73 | Lys 93 | engineered mutation |
Leu 77 | Asp 97 | engineered mutation |
Lys 79 | Trp 99 | engineered mutation |
Ser 87 | Cys 107 | engineered mutation |
Arg 96 | Asn 116 | engineered mutation |
Glu 100 | Tyr 120 | engineered mutation |
Gly 103 | Leu 123 | engineered mutation |
Trp 106 | Tyr 126 | engineered mutation |
Glu 125 | Lys 145 | engineered mutation |
Ala 127 | Ser 147 | engineered mutation |
Thr 132 | Tyr 152 | engineered mutation |
Asn 134 | Lys 154 | engineered mutation |
Ser 179 | - | expression tag |
Ala 180 | - | expression tag |
Trp 181 | - | expression tag |
Ser 182 | - | expression tag |
His 183 | - | expression tag |
Pro 184 | - | expression tag |
Gln 185 | - | expression tag |
Phe 186 | - | expression tag |
Glu 187 | - | expression tag |
Lys 188 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 103140.4 | |
All* | Total formula weight | 103140.4 |