4HIX
Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide
Summary for 4HIX
Entry DOI | 10.2210/pdb4hix/pdb |
Related | 2IPU 3BAE |
Descriptor | Humanized 3D6 Fab heavy chain, Humanized 3D6 Fab light chain, Beta-amyloid protein 40, ... (4 entities in total) |
Functional Keywords | immunoglobulin, immunotherapy candidate, amyloid beta peptide, protein fibril-immune system complex, protein fibril/immune system |
Biological source | homo Sapiens, Mus musculus (human, mouse) More |
Cellular location | Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 3 |
Total formula weight | 51694.54 |
Authors | Miles, L.A.,Crespi, G.A.N.,Parker, M.W. (deposition date: 2012-10-12, release date: 2013-03-13, Last modification date: 2014-03-19) |
Primary citation | Miles, L.A.,Crespi, G.A.,Doughty, L.,Parker, M.W. Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation. Sci Rep, 3:1302-1302, 2013 Cited by PubMed: 23416764DOI: 10.1038/srep01302 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.204 Å) |
Structure validation
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