2G47

Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)

Summary for 2G47
Related2G48 2G49 2G54 2G56
DescriptorInsulin-degrading enzyme, amyloid protein beta A4, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total)
Functional Keywordsprotein-peptide complex, hydrolase
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: P14735
Total number of polymer chains4
Total formula weight238278.20
Authors
Shen, Y.,Tang, W.-J. (deposition date: 2006-02-21, release date: 2006-10-24, Last modification date: 2011-07-13)
Primary citationJoachimiak, A.,Rosner, M.R.,Shen, Y.,Tang, W.J.
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443:870-874, 2006
PubMed: 17051221
DOI: 110.1038/nature05143
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation
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PDB entries from 2021-06-16