2G47
Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Insulin-degrading enzyme | polymer | 990 | 114715.1 | 2 | UniProt (P14735) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) In PDB | Homo sapiens (human) | Insulysin, Insulinase, Insulin protease |
2 | C, D | amyloid protein beta A4 | polymer | 40 | 4335.9 | 2 | Pfam (PF03494) UniProt (by SIFTS) (P05067) In PDB | ||
3 | A, B | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 2 | Chemie (DIO) | |||
4 | water | water | 18.0 | 1066 | Chemie (HOH) |
Sequence modifications
A, B: 42 - 1019 (UniProt: P14735)
PDB | External Database | Details |
---|---|---|
Met 30 | - | initiating methionine |
His 31 | - | expression tag |
His 32 | - | expression tag |
His 33 | - | expression tag |
His 34 | - | expression tag |
His 35 | - | expression tag |
His 36 | - | expression tag |
Ala 37 | - | cloning artifact |
Ala 38 | - | cloning artifact |
Gly 39 | - | cloning artifact |
Ile 40 | - | cloning artifact |
Pro 41 | - | cloning artifact |
Gln 111 | Glu 111 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 238102.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 176.2 | |
All* | Total formula weight | 238278.2 |