4ONG

Fab fragment of 3D6 in complex with amyloid beta 1-40

Summary for 4ONG

Related4ONF
Descriptor3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein, ... (7 entities in total)
Functional Keywordsantibody, amyloid beta peptide, immune system
Biological sourceMus musculus (mouse)
More
Cellular locationMembrane; Single-pass type I membrane protein P05067
Total number of polymer chains3
Total molecular weight54789.84
Authors
Feinberg, H.,Saldanha, J.W.,Diep, L.,Goel, A.,Widom, A.,Veldman, G.M.,Weis, W.I.,Schenk, D.,Basi, G.S. (deposition date: 2014-01-28, release date: 2014-06-11, Last modification date: 2017-11-22)
Primary citation
Feinberg, H.,Saldanha, J.W.,Diep, L.,Goel, A.,Widom, A.,Veldman, G.M.,Weis, W.I.,Schenk, D.,Basi, G.S.
Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6:31-31, 2014
PubMed: 25024748 (PDB entries with the same primary citation)
DOI: 10.1186/alzrt261
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.225301.3%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report