Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4ONG

Fab fragment of 3D6 in complex with amyloid beta 1-40

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 301

Chain	Residue
H	ASP213
H	ASP213
H	HOH406
H	HOH406

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 302

Chain	Residue
H	ASP62
H	IMD315
H	HOH402
H	HOH403

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 303

Chain	Residue
L	ASP172
L	HOH405
L	HOH407
H	HIS170

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 304

Chain	Residue
H	IMD314
H	CL316
H	CL317
H	HOH401

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 305

Chain	Residue
H	CL318
H	CL319
H	HOH405
H	HOH518

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 306

Chain	Residue
H	GLU1
H	ASP179
H	HOH407
H	HOH444

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ZN H 307

Chain	Residue
L	ARG101
L	HOH474
L	HOH475
L	HOH476
P	ASP1
P	PHE4
P	HOH102
P	HOH105

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 308

Chain	Residue
H	LYS65
H	IMD315
H	IMD315
H	CL320
H	CL320

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN H 309

Chain	Residue
H	HOH416
H	HOH478
P	PHE4

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 310

Chain	Residue
H	THR113
H	HOH408
H	HOH409
H	HOH410
H	HOH463

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN H 311

Chain	Residue
H	LYS214
H	HOH452
H	HOH502

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 312

Chain	Residue
H	ARG44
H	GLU46
H	HOH414
H	HOH474

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN H 313

Chain	Residue
H	HOH411
H	HOH412
H	HOH517

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD H 314

Chain	Residue
H	THR200
H	SER209
H	LYS211
H	LYS215
H	ZN304
H	CL316
H	CL317

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE IMD H 315

Chain	Residue
H	TYR60
H	ASP62
H	ZN302
H	ZN308
H	ZN308
H	CL320
H	HOH403
L	PHE99

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 316

Chain	Residue
H	PRO206
H	ZN304
H	IMD314

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 317

Chain	Residue
H	ZN304
H	IMD314

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL H 318

Chain	Residue
H	ASN161
H	SER162
H	ASN202
H	ZN305
H	CL319

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL H 319

Chain	Residue
H	LYS211
H	ASP213
H	ZN305
H	CL318

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CL H 320

Chain	Residue
H	TYR59
H	TYR60
H	LYS65
H	LYS65
H	ZN308
H	ZN308
H	IMD315

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN L 301

Chain	Residue
L	TYR1
L	HIS98

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 302

Chain	Residue
L	HIS194
L	CL319
L	CL320
L	HOH524

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 303

Chain	Residue
L	HOH408
L	HOH408
L	ASP115
L	ASP115

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 304

Chain	Residue
L	HIS203
L	CL316
L	CL317
L	HOH406

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 305

Chain	Residue
L	IMD315
L	HOH401
L	HOH402
L	HOH403

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 306

Chain	Residue
L	ASP170
L	CL318
L	HOH409
L	HOH410

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN L 307

Chain	Residue
L	HOH465

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 308

Chain	Residue
L	LYS154
L	GLU200
L	HOH502
L	HOH523

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN L 309

Chain	Residue
L	GLU84
L	HOH436

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN L 310

Chain	Residue
L	HOH430
L	HOH473
L	HOH522

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN L 311

Chain	Residue
L	GLY157
L	SER196
L	CL321
L	HOH497
L	HOH521

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN L 312

Chain	Residue
L	ASP175

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN L 313

Chain	Residue
L	ASP31
L	HOH411
P	ARG5

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN L 314

Chain	Residue
H	HIS170
L	ASN143
L	ASP172
L	HOH404
L	HOH407

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IMD L 315

Chain	Residue
L	LEU9
L	GLY105
L	GLY106
L	ZN305

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL L 316

Chain	Residue
L	ALA116
L	ALA117
L	HIS203
L	ZN304
L	CL317

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL L 317

Chain	Residue
L	HIS203
L	ZN304
L	CL316

site_id	EC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL L 318

Chain	Residue
L	ASP170
L	ZN306

site_id	EC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL L 319

Chain	Residue
L	HIS194
L	ZN302
L	CL320

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL L 320

Chain	Residue
L	HIS194
L	ZN302
L	CL319
L	HOH500

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL L 321

Chain	Residue
L	ASP156
L	GLY157
L	SER196
L	THR198
L	ZN311

site_id	EC6
Number of Residues	29
Details	BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN

Chain	Residue
H	MET34
H	SER35
H	SER50
H	ILE51
H	ARG52
H	TYR59
H	TYR99
H	SER105
H	SER106
H	ZN307
H	ZN309
H	HOH478
L	ASP31
L	TYR37
L	TRP94
L	GLY96
L	THR97
L	HIS98
L	ARG101
L	ZN313
L	HOH413
L	HOH474
L	HOH475
L	HOH476
P	HOH101
P	HOH102
P	HOH103
P	HOH104
P	HOH105

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR197-HIS203

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:11274207, ECO:0000269\|PubMed:26898943

Chain	Residue	Details
P	HIS6
P	HIS14

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:10413512, ECO:0000305\|PubMed:11274207

Chain	Residue	Details
P	TYR10

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:10413512, ECO:0000269\|PubMed:11274207, ECO:0000269\|PubMed:26898943

Chain	Residue	Details
P	HIS13

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671

Chain	Residue	Details
P	ASP1

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Cleavage; by ACE => ECO:0000269\|PubMed:11604391, ECO:0000269\|PubMed:16154999

Chain	Residue	Details
P	ASP7

site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Cleavage; by alpha-secretase => ECO:0000305\|PubMed:11851430

Chain	Residue	Details
P	LYS16

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Cleavage; by theta-secretase => ECO:0000269\|PubMed:16816112

Chain	Residue	Details
P	PHE19

site_id	SWS_FT_FI8
Number of Residues	1
Details	SITE: Implicated in free radical propagation => ECO:0000250

Chain	Residue	Details
P	GLY33

site_id	SWS_FT_FI9
Number of Residues	1
Details	SITE: Susceptible to oxidation => ECO:0000269\|PubMed:10535332

Chain	Residue	Details
P	MET35

site_id	SWS_FT_FI10
Number of Residues	1
Details	SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305\|PubMed:11851430

Chain	Residue	Details
P	VAL40

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269\|PubMed:22576872

Chain	Residue	Details
P	TYR10

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)