8QN6
Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy
Summary for 8QN6
Entry DOI | 10.2210/pdb8qn6/pdb |
EMDB information | 18508 |
Descriptor | Amyloid-beta A4 protein (1 entity in total) |
Functional Keywords | amyloid-beta, amyloid, filaments, quadruplet, abeta40, human brain, cryo-em, alzheimer's disease, cerebral amyloid angiopathy, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 8671.70 |
Authors | Yang, Y.,Murzin, A.S.,Peak-Chew, S.Y.,Franco, C.,Newell, K.L.,Ghetti, B.,Goedert, M.,Scheres, S.H.W. (deposition date: 2023-09-25, release date: 2023-12-13, Last modification date: 2024-01-31) |
Primary citation | Yang, Y.,Murzin, A.G.,Peak-Chew, S.,Franco, C.,Garringer, H.J.,Newell, K.L.,Ghetti, B.,Goedert, M.,Scheres, S.H.W. Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun, 11:191-191, 2023 Cited by PubMed: 38049918DOI: 10.1186/s40478-023-01694-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.4 Å) |
Structure validation
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