5HOX

X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. Synchrotron data set. (LVFFAEDCGSNKCAII(SAR)LMV).

Summary for 5HOX

Related5HOY 5HOW
DescriptorAmyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) (3 entities in total)
Functional Keywordsamyloid, oligomer, beta-hairpin, alzheimer's, protein fibril, de novo protein
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein P05067
Total number of polymer chains6
Total molecular weight14156.2
Authors
Kreutzer, A.G.,Nowick, J.S.,Spencer, R.K. (deposition date: 2016-01-19, release date: 2016-03-23, Last modification date: 2017-09-13)
Primary citation
Kreutzer, A.G.,Hamza, I.L.,Spencer, R.K.,Nowick, J.S.
X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138:4634-4642, 2016
PubMed: 26967810 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.6b01332
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25130.9%5.2%14.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution