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6VJJ
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BU of 6vjj by Molmil
Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Tran, T.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2020-01-16
Release date:2020-11-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
8JNB
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BU of 8jnb by Molmil
CRAF ras-binding domain chimera, ligand complex
Descriptor: 2-[4-[[(2S)-1-ethanoyl-3-oxidanylidene-2H-indol-2-yl]methyl]-2-methoxy-phenoxy]ethanamide, RAF proto-oncogene serine/threonine-protein kinase, CRaf
Authors:Kawamura, T, Kumasaka, T.
Deposit date:2023-06-06
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers
To Be Published
8T74
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BU of 8t74 by Molmil
Crystal structure of KRAS4a (GMPPNP) in complex with RAF1 (RBD)
Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Whitley, M.J, Simanshu, D.K.
Deposit date:2023-06-19
Release date:2024-02-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.
Sci Adv, 10, 2024
8JNA
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BU of 8jna by Molmil
CRAF ras-binding domain chimera, apo form
Descriptor: RAF proto-oncogene serine/threonine-protein kinase, CRaf
Authors:Kawamura, T, Kumasaka, T.
Deposit date:2023-06-06
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers
To Be Published
1C1Y
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BU of 1c1y by Molmil
CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).
Descriptor: CALCIUM ION, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nassar, N.
Deposit date:1999-07-22
Release date:1999-08-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.
Nature, 375, 1995
3KUC
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BU of 3kuc by Molmil
Complex of Rap1A(E30D/K31E)GDP with RafRBD(A85K/N71R)
Descriptor: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Filchtinski, D, Sharabi, O, Rueppel, A, Vetter, I.R, Herrmann, C, Shifman, J.M.
Deposit date:2009-11-27
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.
J.Mol.Biol., 399, 2010
6XI7
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BU of 6xi7 by Molmil
Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form I)
Descriptor: CHLORIDE ION, Isoform 2B of GTPase KRas, MAGNESIUM ION, ...
Authors:Chan, A.H, Tran, T.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2020-06-19
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
3NY5
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BU of 3ny5 by Molmil
Crystal structure of the RBD domain of serine/threonine-protein kinase B-raf from Homo sapiens. Northeast Structural Genomics Consortium Target HR4694F
Descriptor: Serine/threonine-protein kinase B-raf
Authors:Vorobiev, S, Su, M, Seetharaman, J, Patel, P, Xiao, R, Ciccosanti, C, Shastry, R, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-07-14
Release date:2010-07-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.993 Å)
Cite:Crystal structure of the RBD domain of serine/threonine-protein kinase B-raf from Homo sapiens.
To be Published
1GUA
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BU of 1gua by Molmil
HUMAN RAP1A, RESIDUES 1-167, DOUBLE MUTANT (E30D,K31E) COMPLEXED WITH GPPNHP AND THE RAS-BINDING-DOMAIN OF HUMAN C-RAF1, RESIDUES 51-131
Descriptor: C-RAF1, CALCIUM ION, MAGNESIUM ION, ...
Authors:Nassar, N, Wittinghofer, A.
Deposit date:1996-06-18
Release date:1997-01-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ras/Rap effector specificity determined by charge reversal.
Nat.Struct.Biol., 3, 1996
8EPW
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BU of 8epw by Molmil
Crystal Structure of KRAS4b-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF
Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2022-10-06
Release date:2023-06-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D .
Commun Biol, 6, 2023
6XGV
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BU of 6xgv by Molmil
Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
Descriptor: CHLORIDE ION, GLYCEROL, GTPase KRas, ...
Authors:Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2020-06-18
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
3KUD
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BU of 3kud by Molmil
Complex of Ras-GDP with RafRBD(A85K)
Descriptor: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Filchtinski, D, Sharabi, O, Rueppel, A, Vetter, I.R, Herrmann, C, Shifman, J.M.
Deposit date:2009-11-27
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.
J.Mol.Biol., 399, 2010
4G0N
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BU of 4g0n by Molmil
Crystal Structure of wt H-Ras-GppNHp bound to the RBD of Raf Kinase
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ACETATE ION, CALCIUM ION, ...
Authors:Fetics, S.K, Kearney, B.M, Buhrman, G, Mattos, C.
Deposit date:2012-07-09
Release date:2013-07-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD.
Structure, 23, 2015
6XHB
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BU of 6xhb by Molmil
Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II)
Descriptor: CHLORIDE ION, GLYCEROL, GTPase KRas, ...
Authors:Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2020-06-18
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
8T75
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BU of 8t75 by Molmil
Crystal Structure of KRAS4a (GMPPNP) in complex with RAF1 (RBD-CRD)
Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Whitley, M.J, Simanshu, D.K.
Deposit date:2023-06-19
Release date:2024-02-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.
Sci Adv, 10, 2024
6XGU
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BU of 6xgu by Molmil
Crystal Structure of KRAS-Q61R (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
Descriptor: GLYCEROL, GTPase KRas, MAGNESIUM ION, ...
Authors:Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2020-06-18
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
7JHP
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BU of 7jhp by Molmil
Crystal structure of HRas in complex with the Ras-binding and cysteine-rich domains of CRaf-kinase
Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Cookis, T, Mattos, C.
Deposit date:2020-07-21
Release date:2020-08-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.766 Å)
Cite:Crystal Structure Reveals the Full Ras-Raf Interface and Advances Mechanistic Understanding of Raf Activation.
Biomolecules, 11, 2021
6XHA
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BU of 6xha by Molmil
Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
Descriptor: CHLORIDE ION, GLYCEROL, Isoform 2B of GTPase KRas, ...
Authors:Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2020-06-18
Release date:2021-01-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
6NTC
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BU of 6ntc by Molmil
Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 1 of CRAF Kinase protein
Descriptor: GLYCEROL, GTPase HRas, MAGNESIUM ION, ...
Authors:Maisonneuve, P, Kurinov, I, Wiechmann, S, Ernst, A, Sicheri, F.
Deposit date:2019-01-28
Release date:2020-03-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.
J.Biol.Chem., 295, 2020
6NTD
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BU of 6ntd by Molmil
Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 12 of CRAF Kinase protein
Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Maisonneuve, P, Kurinov, I, Wiechmann, S, Ernst, A, Sicheri, F.
Deposit date:2019-01-28
Release date:2020-03-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.
J.Biol.Chem., 295, 2020
7Z38
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BU of 7z38 by Molmil
Structure of the RAF1-HSP90-CDC37 complex (RHC-I)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G.
Deposit date:2022-03-01
Release date:2022-09-14
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation.
Mol.Cell, 82, 2022
4G3X
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BU of 4g3x by Molmil
Crystal Structure of Q61L H-Ras-GppNHp bound to the RBD of Raf Kinase
Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Fetics, S.K, Kearney, B.M, Buhrman, G, Mattos, C.
Deposit date:2012-07-15
Release date:2013-07-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD.
Structure, 23, 2015
7ZR0
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BU of 7zr0 by Molmil
CryoEM structure of HSP90-CDC37-BRAF(V600E) complex.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Oberoi, J, Pearl, L.H.
Deposit date:2022-05-03
Release date:2022-12-14
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Nat Commun, 13, 2022
8CPD
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BU of 8cpd by Molmil
Cryo-EM structure of CRaf dimer with 14:3:3
Descriptor: 14-3-3 protein zeta isoform X1, RAF proto-oncogene serine/threonine-protein kinase
Authors:Dedden, D, Graedler, U, Schwarz, D, Thomsen, M, Leuthner, B, Schneider, E, Nitsche, J.
Deposit date:2023-03-02
Release date:2024-02-21
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes.
J.Mol.Biol., 436, 2024
7MFD
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BU of 7mfd by Molmil
Autoinhibited BRAF:(14-3-3)2:MEK complex with the BRAF RBD resolved
Descriptor: 14-3-3 protein zeta/delta, Dual specificity mitogen-activated protein kinase kinase 1, N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide, ...
Authors:Martinez Fiesco, J.A, Ping, Z, Durrant, D.E, Morrison, D.K.
Deposit date:2021-04-09
Release date:2022-01-26
Last modified:2022-02-09
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.
Nat Commun, 13, 2022

 

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