8T75

Crystal Structure of KRAS4a (GMPPNP) in complex with RAF1 (RBD-CRD)

Summary for 8T75

• Entry DOI: 10.2210/pdb8t75/pdb
• Descriptor: GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
• Functional Keywords: kras, ras, raf1, craf, oncoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 147967.53

Authors

Whitley, M.J.,Simanshu, D.K. (deposition date: 2023-06-19, release date: 2024-02-14, Last modification date: 2024-02-28)

• Primary citation: Whitley, M.J.,Tran, T.H.,Rigby, M.,Yi, M.,Dharmaiah, S.,Waybright, T.J.,Ramakrishnan, N.,Perkins, S.,Taylor, T.,Messing, S.,Esposito, D.,Nissley, D.V.,McCormick, F.,Stephen, A.G.,Turbyville, T.,Cornilescu, G.,Simanshu, D.K.; Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.; Sci Adv, 10:eadj4137-eadj4137, 2024; PubMed: 38354232; DOI: 10.1126/sciadv.adj4137

Experimental method

X-RAY DIFFRACTION (2.65 Å)