8T75
Crystal Structure of KRAS4a (GMPPNP) in complex with RAF1 (RBD-CRD)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | GTPase KRas | polymer | 178 | 20426.1 | 4 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B, D, F, H (B, D, F, H) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 137 | 15888.4 | 4 | UniProt (P04049) Pfam (PF02196) Pfam (PF00130) | Homo sapiens (human) | Proto-oncogene c-RAF,cRaf,Raf-1 |
| 3 | I, M, Q, U (A, C, E, G) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 4 | Chemie (GNP) | |||
| 4 | J, N, R, V (A, C, E, G) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | K, L, O, P, S... (B, D, F, H) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 6 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 177 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 145258.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2709.3 | |
| All* | Total formula weight | 147967.5 |
