8JNB

CRAF ras-binding domain chimera, ligand complex

Summary for 8JNB

• Entry DOI: 10.2210/pdb8jnb/pdb
• Descriptor: RAF proto-oncogene serine/threonine-protein kinase, CRaf, 2-[4-[[(2S)-1-ethanoyl-3-oxidanylidene-2H-indol-2-yl]methyl]-2-methoxy-phenoxy]ethanamide (3 entities in total)
• Functional Keywords: raf, craf, chimera, beta-grasp, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 10885.41

Authors

Kawamura, T.,Kumasaka, T. (deposition date: 2023-06-06, release date: 2024-06-19, Last modification date: 2024-11-06)

• Primary citation: Yoshikawa, Y.,Makino, Y.,Kubota, H.,Kawamura, T.,Matsumoto, S.,Yuki, H.,Shibaike, A.,Okamura, M.,Okada, T.,Kataoka, T.,Honma, T.,Kumasaka, T.,Koyama, H.,Shima, F.; Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.62 Å)