8JNB
CRAF ras-binding domain chimera, ligand complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | RAF proto-oncogene serine/threonine-protein kinase, CRaf | polymer | 94 | 10517.0 | 1 | UniProt (P04049) UniProt (P15056) Pfam (PF02196) In PDB | Homo sapiens (human) | Proto-oncogene c-RAF,cRaf,Raf-1,Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
2 | B | 2-[4-[[(2S)-1-ethanoyl-3-oxidanylidene-2H-indol-2-yl]methyl]-2-methoxy-phenoxy]ethanamide | non-polymer | 368.4 | 1 | Chemie (USX) | |||
3 | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
B: 50 - 101 (UniProt: P04049)
B: 102 - 113 (UniProt: P15056)
B: 114 - 141 (UniProt: P04049)
PDB | External Database | Details |
---|---|---|
Gly 45 | - | expression tag |
Pro 46 | - | expression tag |
Leu 47 | - | expression tag |
Gly 48 | - | expression tag |
Ser 49 | - | expression tag |
Ser 65 | Lys 65 | engineered mutation |
Tyr 99 | Phe 99 | engineered mutation |
B: 114 - 141 (UniProt: P04049)
PDB | External Database | Details |
---|---|---|
Trp 120 | Ser 120 | engineered mutation |
Glu 129 | Asp 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 10517.0 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 368.4 | |
All* | Total formula weight | 10885.4 |