6NTC
Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 1 of CRAF Kinase protein
Summary for 6NTC
Entry DOI | 10.2210/pdb6ntc/pdb |
Descriptor | GTPase HRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total) |
Functional Keywords | affinity reagent, ras inhibitor, transferase-protein binding complex, transferase/protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 29191.93 |
Authors | Maisonneuve, P.,Kurinov, I.,Wiechmann, S.,Ernst, A.,Sicheri, F. (deposition date: 2019-01-28, release date: 2020-03-04, Last modification date: 2023-10-11) |
Primary citation | Wiechmann, S.,Maisonneuve, P.,Grebbin, B.M.,Hoffmeister, M.,Kaulich, M.,Clevers, H.,Rajalingam, K.,Kurinov, I.,Farin, H.F.,Sicheri, F.,Ernst, A. Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J.Biol.Chem., 295:4526-4540, 2020 Cited by PubMed: 32086379DOI: 10.1074/jbc.RA119.011025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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