4G3X

Crystal Structure of Q61L H-Ras-GppNHp bound to the RBD of Raf Kinase

Summary for 4G3X

• Entry DOI: 10.2210/pdb4g3x/pdb
• Related: 4G0N
• Descriptor: GTPase HRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total)
• Functional Keywords: h-ras, ras, raf kinase, raf, gtpase, allosteric regulation, intrinsic hydrolysis, protein-protein interaction, kinase, gtp binding, hydrolase-transferase complex, hydrolase/transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane. Isoform 2: Nucleus: P01112; Cytoplasm: P04049
• Total number of polymer chains: 2
• Total formula weight: 28196.01

Authors

Fetics, S.K.,Kearney, B.M.,Buhrman, G.,Mattos, C. (deposition date: 2012-07-15, release date: 2013-07-17, Last modification date: 2023-09-13)

• Primary citation: Fetics, S.K.,Guterres, H.,Kearney, B.M.,Buhrman, G.,Ma, B.,Nussinov, R.,Mattos, C.; Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD.; Structure, 23:505-516, 2015; PubMed: 25684575; DOI: 10.1016/j.str.2014.12.017

Experimental method

X-RAY DIFFRACTION (3.25 Å)