7Z38

Structure of the RAF1-HSP90-CDC37 complex (RHC-I)

Summary for 7Z38

• Entry DOI: 10.2210/pdb7z38/pdb
• Related: 7Z37
• EMDB information: 14472 14473
• Descriptor: Heat shock protein HSP 90-beta, RAF proto-oncogene serine/threonine-protein kinase, Hsp90 co-chaperone Cdc37, ... (5 entities in total)
• Functional Keywords: raf1-hsp90-cdc37, complex, proto-oncogene, transferase, serine/threonine kinase, cancer, chaperone
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 290751.00

Authors

Mesa, P.,Garcia-Alonso, S.,Barbacid, M.,Montoya, G. (deposition date: 2022-03-01, release date: 2022-09-14, Last modification date: 2022-09-28)

• Primary citation: Garcia-Alonso, S.,Mesa, P.,Ovejero, L.P.,Aizpurua, G.,Lechuga, C.G.,Zarzuela, E.,Santiveri, C.M.,Sanclemente, M.,Munoz, J.,Musteanu, M.,Campos-Olivas, R.,Martinez-Torrecuadrada, J.,Barbacid, M.,Montoya, G.; Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation.; Mol.Cell, 82:3438-3452.e8, 2022; PubMed: 36055235; DOI: 10.1016/j.molcel.2022.08.012

Experimental method

ELECTRON MICROSCOPY (3.16 Å)