7Z38
Structure of the RAF1-HSP90-CDC37 complex (RHC-I)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Heat shock protein HSP 90-beta | polymer | 732 | 84371.3 | 2 | UniProt (P08238) Pfam (PF13589) Pfam (PF00183) In PDB | Homo sapiens (human) | HSP 90,Heat shock 84 kDa,HSP 84,HSP84 |
2 | C | RAF proto-oncogene serine/threonine-protein kinase | polymer | 659 | 74410.0 | 1 | UniProt (P04049) Pfam (PF02196) Pfam (PF00130) Pfam (PF00069) In PDB | Homo sapiens (human) | Proto-oncogene c-RAF,cRaf,Raf-1 |
3 | D | Hsp90 co-chaperone Cdc37 | polymer | 394 | 46535.5 | 1 | UniProt (Q16543) Pfam (PF03234) Pfam (PF08565) Pfam (PF08564) In PDB | Homo sapiens (human) | Hsp90 chaperone protein kinase-targeting subunit,p50Cdc37 |
4 | A, B | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
5 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A, B: 3 - 724 (UniProt: P08238)
C: 1 - 648 (UniProt: P04049)
D: 1 - 378 (UniProt: Q16543)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
Tyr -6 | - | expression tag |
Pro -5 | - | expression tag |
Tyr -4 | - | expression tag |
Asp -3 | - | expression tag |
Val -2 | - | expression tag |
Pro -1 | - | expression tag |
Asp 0 | - | expression tag |
Tyr 1 | - | expression tag |
Ala 2 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Val 419 | Ile 419 | conflict |
Ile 420 | Val 420 | conflict |
Gly 649 | - | expression tag |
Ser 650 | - | expression tag |
Ala 651 | - | expression tag |
Trp 652 | - | expression tag |
Ser 653 | - | expression tag |
His 654 | - | expression tag |
Pro 655 | - | expression tag |
Gln 656 | - | expression tag |
Phe 657 | - | expression tag |
Glu 658 | - | expression tag |
Lys 659 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Thr 379 | - | expression tag |
Arg 380 | - | expression tag |
Thr 381 | - | expression tag |
Arg 382 | - | expression tag |
Pro 383 | - | expression tag |
Leu 384 | - | expression tag |
Glu 385 | - | expression tag |
Gln 386 | - | expression tag |
Lys 387 | - | expression tag |
Leu 388 | - | expression tag |
Ile 389 | - | expression tag |
Ser 390 | - | expression tag |
Glu 391 | - | expression tag |
Glu 392 | - | expression tag |
Asp 393 | - | expression tag |
Leu 394 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 289688.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1063.0 | |
All* | Total formula weight | 290751.0 |