6NTD
Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 12 of CRAF Kinase protein
Summary for 6NTD
| Entry DOI | 10.2210/pdb6ntd/pdb |
| Descriptor | GTPase HRas, RAF proto-oncogene serine/threonine-protein kinase, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | affinity reagent, engineered protein, ras inhibitor, transferase-protein binding complex, transferase/protein binding |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 29080.83 |
| Authors | Maisonneuve, P.,Kurinov, I.,Wiechmann, S.,Ernst, A.,Sicheri, F. (deposition date: 2019-01-28, release date: 2020-03-04, Last modification date: 2023-10-11) |
| Primary citation | Wiechmann, S.,Maisonneuve, P.,Grebbin, B.M.,Hoffmeister, M.,Kaulich, M.,Clevers, H.,Rajalingam, K.,Kurinov, I.,Farin, H.F.,Sicheri, F.,Ernst, A. Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J.Biol.Chem., 295:4526-4540, 2020 Cited by PubMed: 32086379DOI: 10.1074/jbc.RA119.011025 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
Download full validation report
