6XHA
Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
Summary for 6XHA
Entry DOI | 10.2210/pdb6xha/pdb |
Descriptor | Isoform 2B of GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (8 entities in total) |
Functional Keywords | kras, ras, k-ras, kras4b, g12v, raf1, craf, rbd, ras-binding domain, cysteine-rich domain, crd, oncoprotein, oncoprotein-transferase complex, oncoprotein/transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 36359.87 |
Authors | Tran, T.H.,Chan, A.H.,Dharmaiah, S.,Simanshu, D.K. (deposition date: 2020-06-18, release date: 2021-01-13, Last modification date: 2024-04-03) |
Primary citation | Tran, T.H.,Chan, A.H.,Young, L.C.,Bindu, L.,Neale, C.,Messing, S.,Dharmaiah, S.,Taylor, T.,Denson, J.P.,Esposito, D.,Nissley, D.V.,Stephen, A.G.,McCormick, F.,Simanshu, D.K. KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12:1176-1176, 2021 Cited by PubMed: 33608534DOI: 10.1038/s41467-021-21422-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
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