6XHA
Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue GNP A 201 |
| Chain | Residue |
| A | GLY13 |
| A | TYR32 |
| A | PRO34 |
| A | THR35 |
| A | GLY60 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | VAL14 |
| A | MG203 |
| A | HOH301 |
| A | HOH302 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| A | ASP30 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 202 |
| Chain | Residue |
| A | ARG41 |
| A | GLN43 |
| A | LEU52 |
| B | ASN64 |
| B | THR182 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 203 |
| Chain | Residue |
| A | SER17 |
| A | THR35 |
| A | GNP201 |
| A | HOH301 |
| A | HOH302 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 204 |
| Chain | Residue |
| A | ASP54 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 201 |
| Chain | Residue |
| B | HIS133 |
| B | ASP186 |
| B | SER188 |
| B | HOH302 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue GOL B 202 |
| Chain | Residue |
| B | GLN127 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 203 |
| Chain | Residue |
| B | HIS79 |
| B | ASN115 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 204 |
| Chain | Residue |
| B | HIS139 |
| B | CYS165 |
| B | CYS168 |
| B | CYS184 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 205 |
| Chain | Residue |
| B | CYS152 |
| B | CYS155 |
| B | HIS173 |
| B | CYS176 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 206 |
| Chain | Residue |
| B | LEU62 |
Functional Information from PROSITE/UniProt
| site_id | PS00479 |
| Number of Residues | 46 |
| Details | ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFarktflklaf.CdiCqkfLlngfr.....CqtCgykfHehCstkvptm..C |
| Chain | Residue | Details |
| B | HIS139-CYS184 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 46 |
| Details | Zinc finger: {"description":"Phorbol-ester/DAG-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00226","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
