7MFD

Autoinhibited BRAF:(14-3-3)2:MEK complex with the BRAF RBD resolved

Summary for 7MFD

Entry DOI	10.2210/pdb7mfd/pdb
EMDB information	23813
Descriptor	Serine/threonine-protein kinase B-raf, Dual specificity mitogen-activated protein kinase kinase 1, 14-3-3 protein zeta/delta, ... (5 entities in total)
Functional Keywords	b-raf, mek, 14-3-3, b-raf complex, b-raf monomer, inactive b-raf, serine/threonine-protein kinase b-raf, rbd, signaling protein, signaling protein-transferase complex, signaling protein/transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	184348.10
Authors	Martinez Fiesco, J.A.,Ping, Z.,Durrant, D.E.,Morrison, D.K. (deposition date: 2021-04-09, release date: 2022-01-26, Last modification date: 2022-02-09)
Primary citation	Martinez Fiesco, J.A.,Durrant, D.E.,Morrison, D.K.,Zhang, P. Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding. Nat Commun, 13:486-486, 2022 Cited by PubMed: 35078985 DOI: 10.1038/s41467-022-28084-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.66 Å)

Structure validation