7MFD
Autoinhibited BRAF:(14-3-3)2:MEK complex with the BRAF RBD resolved
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase B-raf | polymer | 766 | 84697.7 | 1 | UniProt (P15056) Pfam (PF02196) Pfam (PF00130) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | B | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 393 | 43493.9 | 1 | UniProt (Q02750) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 3 | C, D | 14-3-3 protein zeta/delta | polymer | 245 | 27777.1 | 2 | UniProt (P63104) Pfam (PF00244) In PDB | Homo sapiens (Human) | Protein kinase C inhibitor protein 1,KCIP-1 |
| 4 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | B | N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide | non-polymer | 471.5 | 1 | Chemie (CHU) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 183745.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 602.3 | |
| All* | Total formula weight | 184348.1 |
