8JNA

CRAF ras-binding domain chimera, apo form

Summary for 8JNA

• Entry DOI: 10.2210/pdb8jna/pdb
• Descriptor: RAF proto-oncogene serine/threonine-protein kinase, CRaf (2 entities in total)
• Functional Keywords: raf, braf, craf, chimera, beta-grasp, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 10517.03

Authors

Kawamura, T.,Kumasaka, T. (deposition date: 2023-06-06, release date: 2024-06-19)

• Primary citation: Yoshikawa, Y.,Makino, Y.,Kubota, H.,Kawamura, T.,Matsumoto, S.,Yuki, H.,Shibaike, A.,Okamura, M.,Okada, T.,Kataoka, T.,Honma, T.,Kumasaka, T.,Koyama, H.,Shima, F.; Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)