8EPW

Crystal Structure of KRAS4b-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF

Summary for 8EPW

• Entry DOI: 10.2210/pdb8epw/pdb
• Related: 8EBZ
• Descriptor: GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total)
• Functional Keywords: kras, ras, k-ras, kras4b, raf1, craf, rbd, ras-binding domain, oncoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 29040.00

Authors

Tran, T.H.,Chan, A.H.,Dharmaiah, S.,Simanshu, D.K. (deposition date: 2022-10-06, release date: 2023-06-07, Last modification date: 2023-10-25)

• Primary citation: Chao, F.A.,Chan, A.H.,Dharmaiah, S.,Schwieters, C.D.,Tran, T.H.,Taylor, T.,Ramakrishnan, N.,Esposito, D.,Nissley, D.V.,McCormick, F.,Simanshu, D.K.,Cornilescu, G.; Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D .; Commun Biol, 6:594-594, 2023; PubMed: 37268708; DOI: 10.1038/s42003-023-04960-6

Experimental method

X-RAY DIFFRACTION (2 Å)