6XGV

Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF

Summary for 6XGV

• Entry DOI: 10.2210/pdb6xgv/pdb
• Descriptor: GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (8 entities in total)
• Functional Keywords: kras, ras, k-ras, kras4b, g13d, raf1, craf, rbd, ras-binding domain, cysteine-rich domain, crd, oncoprotein, oncoprotein-transferase complex, oncoprotein/transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 36237.66

Authors

Tran, T.H.,Chan, A.H.,Dharmaiah, S.,Simanshu, D.K. (deposition date: 2020-06-18, release date: 2021-01-13, Last modification date: 2023-10-18)

• Primary citation: Tran, T.H.,Chan, A.H.,Young, L.C.,Bindu, L.,Neale, C.,Messing, S.,Dharmaiah, S.,Taylor, T.,Denson, J.P.,Esposito, D.,Nissley, D.V.,Stephen, A.G.,McCormick, F.,Simanshu, D.K.; KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.; Nat Commun, 12:1176-1176, 2021; PubMed: 33608534; DOI: 10.1038/s41467-021-21422-x

Experimental method

X-RAY DIFFRACTION (2.11 Å)