Author results

3PDS
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IRREVERSIBLE AGONIST-BETA2 ADRENOCEPTOR COMPLEX
分子名称:Fusion protein Beta-2 adrenergic receptor/Lysozyme, 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, ...
著者Rosenbaum, D.M., Zhang, C., Lyons, J.A., Holl, R., Aragao, D., Arlow, D.H., Rasmussen, S.G.F., Choi, H.-J., DeVree, B.T., Sunahara, R.K., Chae, P.S., Gellman, S.H., Dror, R.O., Shaw, D.E., Weis, W.I., Caffrey, M., Gmeiner, P., Kobilka, B.K.
登録日2010-10-24
公開日2011-01-12
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
Nature, 469, 2011
2RH1
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HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN B2-ADRENERGIC G PROTEIN-COUPLED RECEPTOR.
分子名称:beta-2-adrenergic receptor/T4-lysozyme chimera, MALTOSE, SULFATE ION, ...
著者Cherezov, V., Rosenbaum, D.M., Hanson, M.A., Rasmussen, S.G.F., Thian, F.S., Kobilka, T.S., Choi, H.J., Kuhn, P., Weis, W.I., Kobilka, B.K., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
登録日2007-10-05
公開日2007-10-30
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Science, 318, 2007
5DO7
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CRYSTAL STRUCTURE OF THE HUMAN STEROL TRANSPORTER ABCG5/ABCG8
分子名称:ATP-binding cassette sub-family G member 5, ATP-binding cassette sub-family G member 8
著者Lee, J.-Y., Kinch, L.N., Borek, D.M., Urbatsch, I.L., Xie, X.-S., Grishin, N.V., Cohen, J.C., Otwinowski, Z., Hobbs, H.H., Rosenbaum, D.M.
登録日2015-09-10
公開日2016-05-11
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (3.93 Å)
主引用文献Crystal structure of the human sterol transporter ABCG5/ABCG8.
Nature, 533, 2016
2R4R
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENOCEPTOR
分子名称:Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, light chain, ...
著者Rasmussen, S.G.F., Choi, H.J., Rosenbaum, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K.
登録日2007-08-31
公開日2007-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
2R4S
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENOCEPTOR
分子名称:Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, light chain, ...
著者Rasmussen, S.G.F., Choi, H.J., Rosenbaum, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K.
登録日2007-08-31
公開日2007-11-06
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
3KJ6
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CRYSTAL STRUCTURE OF A METHYLATED BETA2 ADRENERGIC RECEPTOR-FAB COMPLEX
分子名称:Beta-2 adrenergic receptor, Fab light chain, Fab heavy chain, ...
著者Bokoch, M.P., Zou, Y., Rasmussen, S.G.F., Liu, C.W., Nygaard, R., Rosenbaum, D.M., Fung, J.J., Choi, H.-J., Thian, F.S., Kobilka, T.S., Puglisi, J.D., Weis, W.I., Pardo, L., Prosser, S., Mueller, L., Kobilka, B.K.
登録日2009-11-02
公開日2010-02-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.
Nature, 463, 2010
3P0G
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STRUCTURE OF A NANOBODY-STABILIZED ACTIVE STATE OF THE BETA2 ADRENOCEPTOR
分子名称:Beta-2 adrenergic receptor, Lysozyme, Camelid Antibody Fragment, ...
著者Rasmussen, S.G.F., Choi, H.-J., Fung, J.J., Pardon, E., Casarosa, P., Chae, P.S., DeVree, B.T., Rosenbaum, D.M., Thian, F.S., Kobilka, T.S., Schnapp, A., Konetzki, I., Sunahara, R.K., Gellman, S.H., Pautsch, A., Steyaert, J., Weis, W.I., Kobilka, B.K.
登録日2010-09-28
公開日2011-01-19
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structure of a nanobody-stabilized active state of the b2 adrenoceptor
Nature, 469, 2011
4DAJ
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STRUCTURE OF THE M3 MUSCARINIC ACETYLCHOLINE RECEPTOR
分子名称:Muscarinic acetylcholine receptor M3, Lysozyme, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, ...
著者Kruse, A.C., Hu, J., Pan, A.C., Arlow, D.H., Rosenbaum, D.M., Rosemond, E., Green, H.F., Liu, T., Chae, P.S., Dror, R.O., Shaw, D.E., Weis, W.I., Wess, J., Kobilka, B.
登録日2012-01-12
公開日2012-02-22
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure and dynamics of the M3 muscarinic acetylcholine receptor.
Nature, 482, 2012
4S0V
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CRYSTAL STRUCTURE OF THE HUMAN OX2 OREXIN RECEPTOR BOUND TO THE INSOMNIA DRUG SUVOREXANT
分子名称:Human Orexin receptor type 2 fusion protein to P. abysii Glycogen Synthase, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, OLEIC ACID
著者Yin, J., Kolb, P., Mobarec, J.C., Rosenbaum, D.M.
登録日2015-01-06
公開日2015-01-14
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Nature, 519, 2015
4ZJ8
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STRUCTURES OF THE HUMAN OX1 OREXIN RECEPTOR BOUND TO SELECTIVE AND DUAL ANTAGONISTS
分子名称:human OX1R fusion protein to P.abysii glycogen synthase, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, OLEIC ACID
著者Yin, J., Brautigam, C.A., Shao, Z., Clark, L., Harrell, C.M., Gotter, A.L., Coleman, P., Renger, J.J., Rosenbaum, D.M.
登録日2015-04-29
公開日2016-03-09
最終更新日2016-04-13
実験手法X-RAY DIFFRACTION (2.751 Å)
主引用文献Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
4ZJC
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STRUCTURES OF THE HUMAN OX1 OREXIN RECEPTOR BOUND TO SELECTIVE AND DUAL ANTAGONISTS
分子名称:human OX1R fusion protein to P.abysii glycogen synthase, [5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]{(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-1-yl}methanone, OLEIC ACID
著者Yin, J., Brautigam, C.A., Shao, Z., Clark, L., Harrell, C.M., Gotter, A.L., Coleman, P.J., Renger, J.J., Rosenbaum, D.M.
登録日2015-04-29
公開日2016-03-09
最終更新日2016-04-13
実験手法X-RAY DIFFRACTION (2.832 Å)
主引用文献Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
5WQC
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CRYSTAL STRUCTURE OF HUMAN OREXIN 2 RECEPTOR BOUND TO THE SELECTIVE ANTAGONIST EMPA DETERMINED BY THE SYNCHROTRON LIGHT SOURCE AT SPRING-8.
分子名称:Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ...
著者Suno, R., Hirata, K., Yamashita, K., Tsujimoto, H., Sasanuma, M., Horita, S., Yamamoto, M., Rosenbaum, D.M., Iwata, S., Shimamura, T., Kobayashi, T.
登録日2016-11-25
公開日2017-11-29
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA
Structure, 26, 2018
5WS3
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CRYSTAL STRUCTURES OF HUMAN OREXIN 2 RECEPTOR BOUND TO THE SELECTIVE ANTAGONIST EMPA DETERMINED BY SERIAL FEMTOSECOND CRYSTALLOGRAPHY AT SACLA
分子名称:Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ...
著者Suno, R., Kimura, K., Nakane, T., Yamashita, K., Wang, J., Fujiwara, T., Yamanaka, Y., Im, D., Tsujimoto, H., Sasanuma, M., Horita, S., Hirokawa, T., Nango, E., Tono, K., Kameshima, T., Hatsui, T., Joti, Y., Yabashi, M., Shimamoto, K., Yamamoto, M., Rosenbaum, D.M., Iwata, S., Shimamura, T., Kobayashi, T.
登録日2016-12-05
公開日2017-12-13
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
Structure, 26, 2018
6E59
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CRYSTAL STRUCTURE OF THE HUMAN NK1 TACHYKININ RECEPTOR
分子名称:Substance-P receptor, GlgA glycogen synthase, Substance-P receptor chimera, ...
著者Yin, J., Clark, L., Chapman, K., Shao, Z., Borek, D., Xu, Q., Wang, J., Rosenbaum, D.M.
登録日2018-07-19
公開日2018-12-12
最終更新日2019-01-09
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of the human NK1tachykinin receptor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5U09
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HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN CB1 CANNABINOID RECEPTOR
分子名称:Cannabinoid receptor 1,GlgA glycogen synthase, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
著者Shao, Z.H., Yin, J., Rosenbaum, D.
登録日2016-11-23
公開日2016-12-07
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献High-resolution crystal structure of the human CB1 cannabinoid receptor.
Nature, 2016
6KQI
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CRYSTAL STRUCTURE OF PROTEIN1
分子名称:Cannabinoid receptor 1,GlgA glycogen synthase,Cannabinoid receptor 1, 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, 5-chloro-3-ethyl-N-{2-[4-(piperidin-1-yl)phenyl]ethyl}-1H-indole-2-carboxamide, ...
著者Shao, Z.H., Yan, W.
登録日2019-08-17
公開日2019-10-23
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (3.245 Å)
主引用文献Structure of an allosteric modulator bound to the CB1 cannabinoid receptor.
Nat.Chem.Biol., 15, 2019