7CKW

Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex

Summary for 7CKW

• Entry DOI: 10.2210/pdb7ckw/pdb
• EMDB information: 30392
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: transmembrane protein, signaling transduction, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 160553.94

Authors

Yan, W.,Shao, W. (deposition date: 2020-07-20, release date: 2021-03-03)

• Primary citation: Xiao, P.,Yan, W.,Gou, L.,Zhong, Y.N.,Kong, L.,Wu, C.,Wen, X.,Yuan, Y.,Cao, S.,Qu, C.,Yang, X.,Yang, C.C.,Xia, A.,Hu, Z.,Zhang, Q.,He, Y.H.,Zhang, D.L.,Zhang, C.,Hou, G.H.,Liu, H.,Zhu, L.,Fu, P.,Yang, S.,Rosenbaum, D.M.,Sun, J.P.,Du, Y.,Zhang, L.,Yu, X.,Shao, Z.; Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.; Cell, 184:943-956.e18, 2021; PubMed: 33571432; DOI: 10.1016/j.cell.2021.01.028

Experimental method

ELECTRON MICROSCOPY (3.22 Å)