6E59

Crystal structure of the human NK1 tachykinin receptor

Summary for 6E59

Entry DOI	10.2210/pdb6e59/pdb
Descriptor	Substance-P receptor, GlgA glycogen synthase, Substance-P receptor chimera, 1-(4-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1H-1,2,3-triazol-5-yl)-N,N-dimethylmethanamine (2 entities in total)
Functional Keywords	g protein-coupled receptor fusion protein, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	62449.70
Authors	Yin, J.,Clark, L.,Chapman, K.,Shao, Z.,Borek, D.,Xu, Q.,Wang, J.,Rosenbaum, D.M. (deposition date: 2018-07-19, release date: 2018-12-12, Last modification date: 2023-10-11)
Primary citation	Yin, J.,Chapman, K.,Clark, L.D.,Shao, Z.,Borek, D.,Xu, Q.,Wang, J.,Rosenbaum, D.M. Crystal structure of the human NK1tachykinin receptor. Proc. Natl. Acad. Sci. U.S.A., 115:13264-13269, 2018 Cited by PubMed: 30538204 DOI: 10.1073/pnas.1812717115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation