6E59

Crystal structure of the human NK1 tachykinin receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Substance-P receptor, GlgA glycogen synthase, Substance-P receptor chimera	polymer	542	61874.2	1	UniProt (P25103) UniProt (Q9V2J8) Pfam (PF00001) Pfam (PF13692)	Homo sapiens (Human)	SPR,NK-1 receptor,NK-1R,Tachykinin receptor 1,Glycogen synthase
2	B (A)	1-(4-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1H-1,2,3-triazol-5-yl)-N,N-dimethylmethanamine	non-polymer		575.5	1	Chemie (L76)

Sequence modifications

A: 1 - 227 (UniProt: P25103)
A: 1001 - 1196 (UniProt: Q9V2J8)
A: 238 - 346 (UniProt: P25103)

PDB	External Database	Details
His 347	-	expression tag
His 348	-	expression tag
His 349	-	expression tag
His 350	-	expression tag
His 351	-	expression tag
His 352	-	expression tag
His 353	-	expression tag
His 354	-	expression tag
His 355	-	expression tag
His 356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	61874.2
Non-Polymers*	Number of molecules	1
	Total formula weight	575.5
All*	Total formula weight	62449.7

*Water molecules are not included.