8EJC

Structure of FFAR1-Gq complex bound to TAK-875

Summary for 8EJC

• Entry DOI: 10.2210/pdb8ejc/pdb
• EMDB information: 28177
• Descriptor: A modified Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: ffar1, ffas, diabetes, cryoem, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 163947.13

Authors

Kumari, P.,Inoue, A.,Chapman, K.,Lian, P.,Rosenbaum, D.M. (deposition date: 2022-09-16, release date: 2023-05-24, Last modification date: 2023-05-31)

• Primary citation: Kumari, P.,Inoue, A.,Chapman, K.,Lian, P.,Rosenbaum, D.M.; Molecular mechanism of fatty acid activation of FFAR1.; Proc.Natl.Acad.Sci.USA, 120:e2219569120-e2219569120, 2023; PubMed: 37216523; DOI: 10.1073/pnas.2219569120

Experimental method

ELECTRON MICROSCOPY (3 Å)