1HCP | |
1H9U | | THE STRUCTURE OF THE HUMAN RETINOID-X-RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH THE SPECIFIC SYNTHETIC AGONIST LG100268 | | Descriptor: | RETINOID X RECEPTOR, BETA, 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, ... | | Authors: | Schwabe, J.W.R., Love, J.D., Gooch, J.T. | | Deposit date: | 2001-03-21 | | Release date: | 2002-04-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The Structural Basis for the Specificity of Retinoid-X Receptor-Selective Agonists: New Insights Into the Role of Helix H12
J.Biol.Chem., 277, 2002
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1HG4 | |
1HCQ | | THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS | | Descriptor: | DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*AP*GP*TP*GP*AP*CP*CP*T P*G)-3'), DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*TP*GP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (ESTROGEN RECEPTOR), ... | | Authors: | Schwabe, J.W.R., Chapman, L., Finch, J.T., Rhodes, D. | | Deposit date: | 1995-01-04 | | Release date: | 1995-11-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements.
Cell(Cambridge,Mass.), 75, 1993
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6G16 | |
1XC5 | | SOLUTION STRUCTURE OF THE SMRT DEACETYLASE ACTIVATION DOMAIN | | Descriptor: | Nuclear receptor corepressor 2 | | Authors: | Codina, A., Love, J.D., Li, Y., Lazar, M.A., Neuhaus, D., Schwabe, J.W.R. | | Deposit date: | 2004-09-01 | | Release date: | 2005-05-03 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2VSR | | HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 9-(S)-HODE | | Descriptor: | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid | | Authors: | Itoh, T., Fairall, L., Schwabe, J.W.R. | | Deposit date: | 2008-04-29 | | Release date: | 2008-08-19 | | Last modified: | 2012-06-06 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
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2VST | | HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 13-(S)-HODE | | Descriptor: | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid | | Authors: | Itoh, T., Fairall, L., Schwabe, J.W.R. | | Deposit date: | 2008-04-29 | | Release date: | 2008-08-19 | | Last modified: | 2012-06-06 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
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2VV0 | | HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH DHA | | Descriptor: | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID | | Authors: | Itoh, T., Fairall, L., Schwabe, J.W.R. | | Deposit date: | 2008-06-02 | | Release date: | 2008-08-19 | | Last modified: | 2012-06-06 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
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2VV1 | | HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 4-HDHA | | Descriptor: | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid | | Authors: | Itoh, T., Fairall, L., Schwabe, J.W.R. | | Deposit date: | 2008-06-02 | | Release date: | 2008-08-19 | | Last modified: | 2012-06-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
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2VV2 | | HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 5-HEPA | | Descriptor: | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid | | Authors: | Itoh, T., Fairall, L., Schwabe, J.W.R. | | Deposit date: | 2008-06-02 | | Release date: | 2008-08-19 | | Last modified: | 2012-06-06 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
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2VV3 | | HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 4-OXODHA | | Descriptor: | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (6E,10Z,13Z,16Z,19Z)-4-oxodocosa-6,10,13,16,19-pentaenoic acid | | Authors: | Itoh, T., Fairall, L., Schwabe, J.W.R. | | Deposit date: | 2008-06-02 | | Release date: | 2008-08-19 | | Last modified: | 2012-06-06 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural Basis for the Activation of Ppargamma by Oxidized Fatty Acids.
Nat.Struct.Mol.Biol., 15, 2008
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2VV4 | | HPPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH 6-OXOOTE | | Descriptor: | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid, (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid | | Authors: | Itoh, T., Fairall, L., Schwabe, J.W.R. | | Deposit date: | 2008-06-02 | | Release date: | 2008-08-19 | | Last modified: | 2012-06-06 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
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2XTC | | STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN | | Descriptor: | F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X | | Authors: | Oberoi, J., Fairall, L., Watson, P.J., Greenwood, J.A., Schwabe, J.W.R. | | Deposit date: | 2010-10-06 | | Release date: | 2011-01-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery.
Nat.Struct.Mol.Biol., 18, 2011
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2XTD | | STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN | | Descriptor: | TBL1 F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X | | Authors: | Oberoi, J., Fairall, L., Watson, P.J., Greenwood, J.A., Schwabe, J.W.R. | | Deposit date: | 2010-10-06 | | Release date: | 2011-01-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery.
Nat.Struct.Mol.Biol., 18, 2011
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2XTE | | STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN | | Descriptor: | F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X | | Authors: | Oberoi, J., Fairall, L., Watson, P.J., Greenwood, J.A., Schwabe, J.W.R. | | Deposit date: | 2010-10-06 | | Release date: | 2011-01-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery.
Nat.Struct.Mol.Biol., 18, 2011
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2YHN | | THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENT DEGRADATION OF THE LDL RECEPTOR | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE MYLIP, ZINC ION | | Authors: | Fairall, L., Goult, B.T., Millard, C.J., Tontonoz, P., Schwabe, J.W.R. | | Deposit date: | 2011-05-04 | | Release date: | 2011-06-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The Idol-Ube2D Complex Mediates Sterol-Dependent Degradation of the Ldl Receptor.
Genes Dev., 25, 2011
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4A69 | | STRUCTURE OF HDAC3 BOUND TO COREPRESSOR AND INOSITOL TETRAPHOSPHATE | | Descriptor: | HISTONE DEACETYLASE 3,, NUCLEAR RECEPTOR COREPRESSOR 2, ZINC ION, ... | | Authors: | Watson, P.J., Fairall, L., Santos, G.M., Schwabe, J.W.R. | | Deposit date: | 2011-11-01 | | Release date: | 2012-01-11 | | Last modified: | 2012-01-25 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate.
Nature, 481, 2012
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4BKX | | THE STRUCTURE OF HDAC1 IN COMPLEX WITH THE DIMERIC ELM2-SANT DOMAIN OF MTA1 FROM THE NURD COMPLEX | | Descriptor: | METASTASIS-ASSOCIATED PROTEIN MTA1, HISTONE DEACETYLASE 1, ZINC ION, ... | | Authors: | Millard, C.J., Watson, P.J., Celardo, I., Gordiyenko, Y., Cowley, S.M., Robinson, C.V., Fairall, L., Schwabe, J.W.R. | | Deposit date: | 2013-04-30 | | Release date: | 2013-07-03 | | Last modified: | 2013-07-31 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Class I Hdacs Share a Common Mechanism of Regulation by Inositol Phosphates.
Mol.Cell, 51, 2013
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4CP3 | | THE STRUCTURE OF BCL6 BTB (POZ) DOMAIN IN COMPLEX WITH THE ANSAMYCIN ANTIBIOTIC RIFABUTIN. | | Descriptor: | B-CELL LYMPHOMA 6 PROTEIN, RIFABUTIN | | Authors: | Evans, S.E., Fairall, L., Goult, B.T., Jamieson, A.G., Ferrigno, P.K., Ford, R., Wagner, S.D., Schwabe, J.W.R. | | Deposit date: | 2014-01-31 | | Release date: | 2014-03-19 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Ansamycin Antibiotic, Rifamycin Sv, Inhibits Bcl6 Transcriptional Repression and Forms a Complex with the Bcl6-Btb/Poz Domain.
Plos One, 9, 2014
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4D6K | | STRUCTURE OF DNTTIP1 DIMERISATION DOMAIN. | | Descriptor: | DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1 | | Authors: | Itoh, T., Fairall, L., Schwabe, J.W.R. | | Deposit date: | 2014-11-11 | | Release date: | 2015-02-18 | | Last modified: | 2015-03-18 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural and Functional Characterization of a Cell Cycle Associated Hdac1/2 Complex Reveals the Structural Basis for Complex Assembly and Nucleosome Targeting.
Nucleic Acids Res., 43, 2015
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6GQF | | THE STRUCTURE OF MOUSE ASTERA (GRAMD1A) WITH 25-HYDROXY CHOLESTEROL | | Descriptor: | GRAM domain-containing protein 1A, 25-HYDROXYCHOLESTEROL, GLYCEROL | | Authors: | Fairall, L., Gurnett, J.E., Vashi, D., Sandhu, J., Tontonoz, P., Schwabe, J.W.R. | | Deposit date: | 2018-06-07 | | Release date: | 2018-09-26 | | Last modified: | 2018-10-17 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.
Cell, 175, 2018
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2MWI | | THE STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF DNTTIP1 | | Descriptor: | Deoxynucleotidyltransferase terminal-interacting protein 1 | | Authors: | Schwabe, J.W.R., Muskett, F.W., Itoh, T. | | Deposit date: | 2014-11-11 | | Release date: | 2015-02-18 | | Last modified: | 2015-03-18 | | Method: | SOLUTION NMR | | Cite: | Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting.
Nucleic Acids Res., 43, 2015
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1ZFD | | SWI5 ZINC FINGER DOMAIN 2, NMR, 45 STRUCTURES | | Descriptor: | SWI5, ZINC ION | | Authors: | Neuhaus, D., Nakaseko, Y., Schwabe, J.W.R., Rhodes, D., Klug, A. | | Deposit date: | 1996-04-04 | | Release date: | 1996-10-14 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution structures of two zinc-finger domains from SWI5 obtained using two-dimensional 1H nuclear magnetic resonance spectroscopy. A zinc-finger structure with a third strand of beta-sheet.
J.Mol.Biol., 228, 1992
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2DRP | | THE CRYSTAL STRUCTURE OF A TWO ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER/DNA RECOGNITION | | Descriptor: | DNA (5'-D(*CP*TP*AP*AP*TP*AP*AP*GP*GP*AP*TP*AP*AP*CP*GP*TP*C P*CP*G)-3'), DNA (5'-D(*TP*CP*GP*GP*AP*CP*GP*TP*TP*AP*TP*CP*CP*TP*TP*AP*T P*TP*A)-3'), PROTEIN (TRAMTRACK DNA-BINDING DOMAIN), ... | | Authors: | Fairall, L., Schwabe, J.W.R., Chapman, L., Finch, J.T., Rhodes, D. | | Deposit date: | 1994-06-06 | | Release date: | 1994-08-31 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition.
Nature, 366, 1993
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