1HCP

DNA RECOGNITION BY THE OESTROGEN RECEPTOR: FROM SOLUTION TO THE CRYSTAL

Summary for 1HCP

• Entry DOI: 10.2210/pdb1hcp/pdb
• Descriptor: HUMAN/CHICKEN ESTROGEN RECEPTOR, ZINC ION (2 entities in total)
• Functional Keywords: transcription regulation
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
• Total number of polymer chains: 1
• Total formula weight: 8898.98

Authors

Schwabe, J.W.R.,Rhodes, D.,Neuhaus, D. (deposition date: 1993-11-23, release date: 1995-11-23, Last modification date: 2024-05-22)

Primary citation

Schwabe, J.W.,Chapman, L.,Finch, J.T.,Rhodes, D.,Neuhaus, D.
DNA recognition by the oestrogen receptor: from solution to the crystal.
Structure, 1:187-204, 1993

PubMed Abstract: The steroid/nuclear hormone receptors are a large family of conserved ligand-activated transcription factors that regulate gene expression through binding to response elements upstream of their target genes. Most members of this family bind to DNA as homodimers or heterodimers and recognize the sequence, spacing and orientation of the two half-sites of their response elements. The recognition and discrimination of the sequence and arrangements of these half-sites are mediated primarily by a highly conserved DNA-binding domain.

PubMed: 16100953
DOI: 10.1016/0969-2126(93)90020-H

Experimental method

SOLUTION NMR