1H9U

The structure of the human retinoid-X-receptor beta ligand binding domain in complex with the specific synthetic agonist LG100268

Summary for 1H9U

DescriptorRETINOID X RECEPTOR, BETA, 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, NICKEL (II) ION, ... (5 entities in total)
Functional Keywordsnuclear receptor, rxr, transcription factor
Biological sourceHOMO SAPIENS
Cellular locationNucleus P28702
Total number of polymer chains4
Total molecular weight101130.23
Authors
Schwabe, J.W.R.,Love, J.D.,Gooch, J.T. (deposition date: 2001-03-21, release date: 2002-04-03, Last modification date: 2011-07-13)
Primary citation
Love, J.D.,Gooch, J.T.,Benko, S.,Li, C.,Nagy, L.,Chatterjee, V.K.K.,Evans, R.M.,Schwabe, J.W.R.
The Structural Basis for the Specificity of Retinoid-X Receptor-Selective Agonists: New Insights Into the Role of Helix H12
J.Biol.Chem., 277:11385-, 2002
PubMed: 11782480 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M110869200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers220.9%6.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1h9u.pdb1.gz [254.1 KB])