1H9U
The structure of the human retinoid-X-receptor beta ligand binding domain in complex with the specific synthetic agonist LG100268
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003707 | molecular_function | nuclear steroid receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003707 | molecular_function | nuclear steroid receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI A 2 |
| Chain | Residue |
| A | CL3 |
| A | HIS402 |
| A | HIS404 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 3 |
| Chain | Residue |
| A | NI2 |
| A | HIS404 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI B 2 |
| Chain | Residue |
| B | CL3 |
| B | HIS402 |
| B | HIS404 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 3 |
| Chain | Residue |
| B | HIS404 |
| B | NI2 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NI C 2 |
| Chain | Residue |
| C | HIS402 |
| C | HIS404 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NI D 2 |
| Chain | Residue |
| D | HIS402 |
| D | HIS404 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE LG2 A 1 |
| Chain | Residue |
| A | ILE339 |
| A | ALA342 |
| A | ALA343 |
| A | GLN346 |
| A | TRP376 |
| A | LEU380 |
| A | ILE381 |
| A | PHE384 |
| A | ARG387 |
| A | LEU397 |
| A | ALA398 |
| A | ILE416 |
| A | CYS503 |
| A | HIS506 |
| A | HOH2001 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE LG2 B 1 |
| Chain | Residue |
| B | ILE339 |
| B | ALA342 |
| B | ALA343 |
| B | GLN346 |
| B | LEU380 |
| B | ILE381 |
| B | PHE384 |
| B | ARG387 |
| B | LEU397 |
| B | ALA398 |
| B | ILE416 |
| B | CYS503 |
| B | HIS506 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE LG2 C 1 |
| Chain | Residue |
| C | ILE339 |
| C | ALA342 |
| C | ALA343 |
| C | GLN346 |
| C | TRP376 |
| C | LEU380 |
| C | ILE381 |
| C | ARG387 |
| C | LEU397 |
| C | ALA398 |
| C | CYS503 |
| C | HIS506 |
| C | HOH2001 |
| site_id | BC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE LG2 D 1 |
| Chain | Residue |
| D | ILE339 |
| D | ALA342 |
| D | ALA343 |
| D | GLN346 |
| D | TRP376 |
| D | LEU380 |
| D | ILE381 |
| D | PHE384 |
| D | ARG387 |
| D | LEU397 |
| D | ALA398 |
| D | ILE416 |
| D | CYS503 |
| D | HIS506 |
