6Z2K

The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex

Summary for 6Z2K

• Entry DOI: 10.2210/pdb6z2k/pdb
• EMDB information: 11042
• Descriptor: Histone deacetylase 1, Deoxynucleotidyltransferase terminal-interacting protein 1, Mitotic deacetylase-associated SANT domain protein, ... (6 entities in total)
• Functional Keywords: hdac1 mideas elmsan1 dnttip1 tdif1 histone deacetylase midac, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 360634.44

Authors

Fairall, L.,Saleh, A.,Ragan, T.J.,Millard, C.J.,Savva, C.G.,Schwabe, J.W.R. (deposition date: 2020-05-16, release date: 2020-07-08, Last modification date: 2020-10-07)

• Primary citation: Turnbull, R.E.,Fairall, L.,Saleh, A.,Kelsall, E.,Morris, K.L.,Ragan, T.J.,Savva, C.G.,Chandru, A.,Millard, C.J.,Makarova, O.V.,Smith, C.J.,Roseman, A.M.,Fry, A.M.,Cowley, S.M.,Schwabe, J.W.R.; The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure.; Nat Commun, 11:3252-3252, 2020; PubMed: 32591534; DOI: 10.1038/s41467-020-17078-8

Experimental method

ELECTRON MICROSCOPY (4.5 Å)