6Z2K

The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000118	cellular_component	histone deacetylase complex
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000785	cellular_component	chromatin
C	0000792	cellular_component	heterochromatin
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
C	0001046	molecular_function	core promoter sequence-specific DNA binding
C	0001222	molecular_function	transcription corepressor binding
C	0002039	molecular_function	p53 binding
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003714	molecular_function	transcription corepressor activity
C	0004407	molecular_function	histone deacetylase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005667	cellular_component	transcription regulator complex
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006476	biological_process	protein deacetylation
C	0007492	biological_process	endoderm development
C	0007623	biological_process	circadian rhythm
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009913	biological_process	epidermal cell differentiation
C	0010628	biological_process	positive regulation of gene expression
C	0010629	biological_process	negative regulation of gene expression
C	0010832	biological_process	negative regulation of myotube differentiation
C	0016581	cellular_component	NuRD complex
C	0016787	molecular_function	hydrolase activity
C	0017053	cellular_component	transcription repressor complex
C	0019899	molecular_function	enzyme binding
C	0021766	biological_process	hippocampus development
C	0030182	biological_process	neuron differentiation
C	0030336	biological_process	negative regulation of cell migration
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0031078	molecular_function	histone H3K14 deacetylase activity, hydrolytic mechanism
C	0031492	molecular_function	nucleosomal DNA binding
C	0031507	biological_process	heterochromatin formation
C	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
C	0032922	biological_process	circadian regulation of gene expression
C	0032991	cellular_component	protein-containing complex
C	0033558	molecular_function	protein lysine deacetylase activity
C	0034739	molecular_function	histone H4K16 deacetylase activity, hydrolytic mechanism
C	0035851	molecular_function	Krueppel-associated box domain binding
C	0036120	biological_process	cellular response to platelet-derived growth factor stimulus
C	0042475	biological_process	odontogenesis of dentin-containing tooth
C	0042659	biological_process	regulation of cell fate specification
C	0042733	biological_process	embryonic digit morphogenesis
C	0042826	molecular_function	histone deacetylase binding
C	0042903	molecular_function	tubulin deacetylase activity
C	0043025	cellular_component	neuronal cell body
C	0043066	biological_process	negative regulation of apoptotic process
C	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
C	0043922	biological_process	negative regulation by host of viral transcription
C	0045814	biological_process	negative regulation of gene expression, epigenetic
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046872	molecular_function	metal ion binding
C	0048511	biological_process	rhythmic process
C	0048661	biological_process	positive regulation of smooth muscle cell proliferation
C	0048709	biological_process	oligodendrocyte differentiation
C	0048714	biological_process	positive regulation of oligodendrocyte differentiation
C	0051059	molecular_function	NF-kappaB binding
C	0060766	biological_process	negative regulation of androgen receptor signaling pathway
C	0060789	biological_process	hair follicle placode formation
C	0061029	biological_process	eyelid development in camera-type eye
C	0061198	biological_process	fungiform papilla formation
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0070822	cellular_component	Sin3-type complex
C	0070888	molecular_function	E-box binding
C	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0140937	molecular_function	histone H4K12 deacetylase activity, hydrolytic mechanism
C	0160008	molecular_function	protein decrotonylase activity
C	0160009	molecular_function	histone decrotonylase activity
C	0160216	molecular_function	protein lysine delactylase activity
C	0180032	molecular_function	histone H4K5 deacetylase activity, hydrolytic mechanism
C	0180033	molecular_function	histone H4K8 deacetylase activity, hydrolytic mechanism
C	1902455	biological_process	negative regulation of stem cell population maintenance
C	1902459	biological_process	positive regulation of stem cell population maintenance
C	1990162	molecular_function	histone H3K4 deacetylase activity, hydrolytic mechanism
C	1990841	molecular_function	promoter-specific chromatin binding
C	2000273	biological_process	positive regulation of signaling receptor activity
C	2000736	biological_process	regulation of stem cell differentiation
C	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
E	0000118	cellular_component	histone deacetylase complex
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000785	cellular_component	chromatin
E	0000792	cellular_component	heterochromatin
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
E	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
E	0001046	molecular_function	core promoter sequence-specific DNA binding
E	0001222	molecular_function	transcription corepressor binding
E	0002039	molecular_function	p53 binding
E	0003677	molecular_function	DNA binding
E	0003682	molecular_function	chromatin binding
E	0003714	molecular_function	transcription corepressor activity
E	0004407	molecular_function	histone deacetylase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005667	cellular_component	transcription regulator complex
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006325	biological_process	chromatin organization
E	0006338	biological_process	chromatin remodeling
E	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006476	biological_process	protein deacetylation
E	0007492	biological_process	endoderm development
E	0007623	biological_process	circadian rhythm
E	0008284	biological_process	positive regulation of cell population proliferation
E	0009913	biological_process	epidermal cell differentiation
E	0010628	biological_process	positive regulation of gene expression
E	0010629	biological_process	negative regulation of gene expression
E	0010832	biological_process	negative regulation of myotube differentiation
E	0016581	cellular_component	NuRD complex
E	0016787	molecular_function	hydrolase activity
E	0017053	cellular_component	transcription repressor complex
E	0019899	molecular_function	enzyme binding
E	0021766	biological_process	hippocampus development
E	0030182	biological_process	neuron differentiation
E	0030336	biological_process	negative regulation of cell migration
E	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
E	0031078	molecular_function	histone H3K14 deacetylase activity, hydrolytic mechanism
E	0031492	molecular_function	nucleosomal DNA binding
E	0031507	biological_process	heterochromatin formation
E	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
E	0032922	biological_process	circadian regulation of gene expression
E	0032991	cellular_component	protein-containing complex
E	0033558	molecular_function	protein lysine deacetylase activity
E	0034739	molecular_function	histone H4K16 deacetylase activity, hydrolytic mechanism
E	0035851	molecular_function	Krueppel-associated box domain binding
E	0036120	biological_process	cellular response to platelet-derived growth factor stimulus
E	0042475	biological_process	odontogenesis of dentin-containing tooth
E	0042659	biological_process	regulation of cell fate specification
E	0042733	biological_process	embryonic digit morphogenesis
E	0042826	molecular_function	histone deacetylase binding
E	0042903	molecular_function	tubulin deacetylase activity
E	0043025	cellular_component	neuronal cell body
E	0043066	biological_process	negative regulation of apoptotic process
E	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
E	0043922	biological_process	negative regulation by host of viral transcription
E	0045814	biological_process	negative regulation of gene expression, epigenetic
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046872	molecular_function	metal ion binding
E	0048511	biological_process	rhythmic process
E	0048661	biological_process	positive regulation of smooth muscle cell proliferation
E	0048709	biological_process	oligodendrocyte differentiation
E	0048714	biological_process	positive regulation of oligodendrocyte differentiation
E	0051059	molecular_function	NF-kappaB binding
E	0060766	biological_process	negative regulation of androgen receptor signaling pathway
E	0060789	biological_process	hair follicle placode formation
E	0061029	biological_process	eyelid development in camera-type eye
E	0061198	biological_process	fungiform papilla formation
E	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
E	0070822	cellular_component	Sin3-type complex
E	0070888	molecular_function	E-box binding
E	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
E	0140297	molecular_function	DNA-binding transcription factor binding
E	0140937	molecular_function	histone H4K12 deacetylase activity, hydrolytic mechanism
E	0160008	molecular_function	protein decrotonylase activity
E	0160009	molecular_function	histone decrotonylase activity
E	0160216	molecular_function	protein lysine delactylase activity
E	0180032	molecular_function	histone H4K5 deacetylase activity, hydrolytic mechanism
E	0180033	molecular_function	histone H4K8 deacetylase activity, hydrolytic mechanism
E	1902455	biological_process	negative regulation of stem cell population maintenance
E	1902459	biological_process	positive regulation of stem cell population maintenance
E	1990162	molecular_function	histone H3K4 deacetylase activity, hydrolytic mechanism
E	1990841	molecular_function	promoter-specific chromatin binding
E	2000273	biological_process	positive regulation of signaling receptor activity
E	2000736	biological_process	regulation of stem cell differentiation
E	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
I	0000118	cellular_component	histone deacetylase complex
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000785	cellular_component	chromatin
I	0000792	cellular_component	heterochromatin
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
I	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
I	0001046	molecular_function	core promoter sequence-specific DNA binding
I	0001222	molecular_function	transcription corepressor binding
I	0002039	molecular_function	p53 binding
I	0003677	molecular_function	DNA binding
I	0003682	molecular_function	chromatin binding
I	0003714	molecular_function	transcription corepressor activity
I	0004407	molecular_function	histone deacetylase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005667	cellular_component	transcription regulator complex
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006325	biological_process	chromatin organization
I	0006338	biological_process	chromatin remodeling
I	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006476	biological_process	protein deacetylation
I	0007492	biological_process	endoderm development
I	0007623	biological_process	circadian rhythm
I	0008284	biological_process	positive regulation of cell population proliferation
I	0009913	biological_process	epidermal cell differentiation
I	0010628	biological_process	positive regulation of gene expression
I	0010629	biological_process	negative regulation of gene expression
I	0010832	biological_process	negative regulation of myotube differentiation
I	0016581	cellular_component	NuRD complex
I	0016787	molecular_function	hydrolase activity
I	0017053	cellular_component	transcription repressor complex
I	0019899	molecular_function	enzyme binding
I	0021766	biological_process	hippocampus development
I	0030182	biological_process	neuron differentiation
I	0030336	biological_process	negative regulation of cell migration
I	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
I	0031078	molecular_function	histone H3K14 deacetylase activity, hydrolytic mechanism
I	0031492	molecular_function	nucleosomal DNA binding
I	0031507	biological_process	heterochromatin formation
I	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
I	0032922	biological_process	circadian regulation of gene expression
I	0032991	cellular_component	protein-containing complex
I	0033558	molecular_function	protein lysine deacetylase activity
I	0034739	molecular_function	histone H4K16 deacetylase activity, hydrolytic mechanism
I	0035851	molecular_function	Krueppel-associated box domain binding
I	0036120	biological_process	cellular response to platelet-derived growth factor stimulus
I	0042475	biological_process	odontogenesis of dentin-containing tooth
I	0042659	biological_process	regulation of cell fate specification
I	0042733	biological_process	embryonic digit morphogenesis
I	0042826	molecular_function	histone deacetylase binding
I	0042903	molecular_function	tubulin deacetylase activity
I	0043025	cellular_component	neuronal cell body
I	0043066	biological_process	negative regulation of apoptotic process
I	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
I	0043922	biological_process	negative regulation by host of viral transcription
I	0045814	biological_process	negative regulation of gene expression, epigenetic
I	0045892	biological_process	negative regulation of DNA-templated transcription
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046872	molecular_function	metal ion binding
I	0048511	biological_process	rhythmic process
I	0048661	biological_process	positive regulation of smooth muscle cell proliferation
I	0048709	biological_process	oligodendrocyte differentiation
I	0048714	biological_process	positive regulation of oligodendrocyte differentiation
I	0051059	molecular_function	NF-kappaB binding
I	0060766	biological_process	negative regulation of androgen receptor signaling pathway
I	0060789	biological_process	hair follicle placode formation
I	0061029	biological_process	eyelid development in camera-type eye
I	0061198	biological_process	fungiform papilla formation
I	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
I	0070822	cellular_component	Sin3-type complex
I	0070888	molecular_function	E-box binding
I	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
I	0140297	molecular_function	DNA-binding transcription factor binding
I	0140937	molecular_function	histone H4K12 deacetylase activity, hydrolytic mechanism
I	0160008	molecular_function	protein decrotonylase activity
I	0160009	molecular_function	histone decrotonylase activity
I	0160216	molecular_function	protein lysine delactylase activity
I	0180032	molecular_function	histone H4K5 deacetylase activity, hydrolytic mechanism
I	0180033	molecular_function	histone H4K8 deacetylase activity, hydrolytic mechanism
I	1902455	biological_process	negative regulation of stem cell population maintenance
I	1902459	biological_process	positive regulation of stem cell population maintenance
I	1990162	molecular_function	histone H3K4 deacetylase activity, hydrolytic mechanism
I	1990841	molecular_function	promoter-specific chromatin binding
I	2000273	biological_process	positive regulation of signaling receptor activity
I	2000736	biological_process	regulation of stem cell differentiation
I	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
K	0000118	cellular_component	histone deacetylase complex
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000785	cellular_component	chromatin
K	0000792	cellular_component	heterochromatin
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
K	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
K	0001046	molecular_function	core promoter sequence-specific DNA binding
K	0001222	molecular_function	transcription corepressor binding
K	0002039	molecular_function	p53 binding
K	0003677	molecular_function	DNA binding
K	0003682	molecular_function	chromatin binding
K	0003714	molecular_function	transcription corepressor activity
K	0004407	molecular_function	histone deacetylase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005667	cellular_component	transcription regulator complex
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006325	biological_process	chromatin organization
K	0006338	biological_process	chromatin remodeling
K	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006476	biological_process	protein deacetylation
K	0007492	biological_process	endoderm development
K	0007623	biological_process	circadian rhythm
K	0008284	biological_process	positive regulation of cell population proliferation
K	0009913	biological_process	epidermal cell differentiation
K	0010628	biological_process	positive regulation of gene expression
K	0010629	biological_process	negative regulation of gene expression
K	0010832	biological_process	negative regulation of myotube differentiation
K	0016581	cellular_component	NuRD complex
K	0016787	molecular_function	hydrolase activity
K	0017053	cellular_component	transcription repressor complex
K	0019899	molecular_function	enzyme binding
K	0021766	biological_process	hippocampus development
K	0030182	biological_process	neuron differentiation
K	0030336	biological_process	negative regulation of cell migration
K	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
K	0031078	molecular_function	histone H3K14 deacetylase activity, hydrolytic mechanism
K	0031492	molecular_function	nucleosomal DNA binding
K	0031507	biological_process	heterochromatin formation
K	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
K	0032922	biological_process	circadian regulation of gene expression
K	0032991	cellular_component	protein-containing complex
K	0033558	molecular_function	protein lysine deacetylase activity
K	0034739	molecular_function	histone H4K16 deacetylase activity, hydrolytic mechanism
K	0035851	molecular_function	Krueppel-associated box domain binding
K	0036120	biological_process	cellular response to platelet-derived growth factor stimulus
K	0042475	biological_process	odontogenesis of dentin-containing tooth
K	0042659	biological_process	regulation of cell fate specification
K	0042733	biological_process	embryonic digit morphogenesis
K	0042826	molecular_function	histone deacetylase binding
K	0042903	molecular_function	tubulin deacetylase activity
K	0043025	cellular_component	neuronal cell body
K	0043066	biological_process	negative regulation of apoptotic process
K	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
K	0043922	biological_process	negative regulation by host of viral transcription
K	0045814	biological_process	negative regulation of gene expression, epigenetic
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0046872	molecular_function	metal ion binding
K	0048511	biological_process	rhythmic process
K	0048661	biological_process	positive regulation of smooth muscle cell proliferation
K	0048709	biological_process	oligodendrocyte differentiation
K	0048714	biological_process	positive regulation of oligodendrocyte differentiation
K	0051059	molecular_function	NF-kappaB binding
K	0060766	biological_process	negative regulation of androgen receptor signaling pathway
K	0060789	biological_process	hair follicle placode formation
K	0061029	biological_process	eyelid development in camera-type eye
K	0061198	biological_process	fungiform papilla formation
K	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
K	0070822	cellular_component	Sin3-type complex
K	0070888	molecular_function	E-box binding
K	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
K	0140297	molecular_function	DNA-binding transcription factor binding
K	0140937	molecular_function	histone H4K12 deacetylase activity, hydrolytic mechanism
K	0160008	molecular_function	protein decrotonylase activity
K	0160009	molecular_function	histone decrotonylase activity
K	0160216	molecular_function	protein lysine delactylase activity
K	0180032	molecular_function	histone H4K5 deacetylase activity, hydrolytic mechanism
K	0180033	molecular_function	histone H4K8 deacetylase activity, hydrolytic mechanism
K	1902455	biological_process	negative regulation of stem cell population maintenance
K	1902459	biological_process	positive regulation of stem cell population maintenance
K	1990162	molecular_function	histone H3K4 deacetylase activity, hydrolytic mechanism
K	1990841	molecular_function	promoter-specific chromatin binding
K	2000273	biological_process	positive regulation of signaling receptor activity
K	2000736	biological_process	regulation of stem cell differentiation
K	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN C 501

Chain	Residue
C	ASP176
C	HIS178
C	ASP264

---

site_id	AC2
Number of Residues	5
Details	binding site for residue K C 502

Chain	Residue
C	ASP174
C	ASP176
C	HIS178
C	SER197
C	PHE198

---

site_id	AC3
Number of Residues	4
Details	binding site for residue K C 503

Chain	Residue
C	THR190
C	VAL193
C	TYR222
C	PHE187

---

site_id	AC4
Number of Residues	4
Details	binding site for residue IHP E 501

Chain	Residue
E	GLY27
E	LYS31
F	LYS875
L	LYS839

---

site_id	AC5
Number of Residues	3
Details	binding site for residue ZN E 502

Chain	Residue
E	ASP176
E	HIS178
E	ASP264

---

site_id	AC6
Number of Residues	5
Details	binding site for residue K E 503

Chain	Residue
E	ASP174
E	ASP176
E	HIS178
E	SER197
E	PHE198

---

site_id	AC7
Number of Residues	4
Details	binding site for residue K E 504

Chain	Residue
E	PHE187
E	THR190
E	VAL193
E	TYR222

---

site_id	AC8
Number of Residues	3
Details	binding site for residue ZN K 501

Chain	Residue
K	ASP176
K	HIS178
K	ASP264

---

site_id	AC9
Number of Residues	5
Details	binding site for residue K K 502

Chain	Residue
K	ASP174
K	ASP176
K	HIS178
K	SER197
K	PHE198

---

site_id	AD1
Number of Residues	4
Details	binding site for residue K K 503

Chain	Residue
K	PHE187
K	THR190
K	VAL193
K	TYR222

---

site_id	AD2
Number of Residues	3
Details	binding site for residue ZN I 501

Chain	Residue
I	ASP176
I	HIS178
I	ASP264

---

site_id	AD3
Number of Residues	5
Details	binding site for residue K I 502

Chain	Residue
I	ASP174
I	ASP176
I	HIS178
I	SER197
I	PHE198

---

site_id	AD4
Number of Residues	4
Details	binding site for residue K I 503

Chain	Residue
I	PHE187
I	THR190
I	VAL193
I	TYR222

---

site_id	AD5
Number of Residues	5
Details	binding site for residue IHP F 901

Chain	Residue
F	LYS839
F	LYS843
K	ARG270
L	TYR871
L	LYS875

---

site_id	AD6
Number of Residues	5
Details	binding site for residue IHP D 901

Chain	Residue
D	LYS839
D	LYS843
I	GLY27
I	LYS31
J	LYS875

---

site_id	AD7
Number of Residues	4
Details	binding site for residue IHP J 901

Chain	Residue
C	GLY27
D	TYR871
J	LYS839
J	LYS843

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:19182791, ECO:0000269|PubMed:28497810

Chain	Residue	Details
C	HIS141
E	HIS141
K	HIS141
I	HIS141

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O15379

Chain	Residue	Details
C	GLY27
E	HIS178
E	ASP264
E	ARG270
K	GLY27
K	LYS31
K	ASP176
K	HIS178
K	ASP264
K	ARG270
I	GLY27
C	LYS31
I	LYS31
I	ASP176
I	HIS178
I	ASP264
I	ARG270
C	ASP176
C	HIS178
C	ASP264
C	ARG270
E	GLY27
E	LYS31
E	ASP176

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS74
E	LYS74
K	LYS74
I	LYS74

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS220
E	LYS220
K	LYS220
I	LYS220

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P70288

Chain	Residue	Details
C	CYS261
C	CYS273
E	CYS261
E	CYS273
K	CYS261
K	CYS273
I	CYS261
I	CYS273

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:17487921, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	SER393
E	SER393
K	SER393
I	SER393

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q92769

Chain	Residue	Details
C	SER406
E	SER406
K	SER406
I	SER406

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER409
E	SER409
K	SER409
I	SER409

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:11602581, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER421
E	SER421
K	SER421
I	SER421

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:11602581, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER423
E	SER423
K	SER423
I	SER423

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: N6-methylated lysine; by EHMT2 => ECO:0000269|PubMed:18438403

Chain	Residue	Details
C	LYS432
E	LYS432
K	LYS432
I	LYS432

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q92769

Chain	Residue	Details
C	LYS74
E	LYS74
K	LYS74
I	LYS74

---

site_id	SWS_FT_FI13
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
I	LYS438
I	LYS480
C	LYS438
C	LYS480
E	LYS438
E	LYS480
K	LYS438
K	LYS480

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297

Chain	Residue	Details
C	LYS444
E	LYS444
K	LYS444
I	LYS444

---

site_id	SWS_FT_FI15
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:Q92769

Chain	Residue	Details
C	LYS456
C	LYS473
E	LYS456
E	LYS473
K	LYS456
K	LYS473
I	LYS456
I	LYS473

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447

Chain	Residue	Details
C	LYS457
E	LYS457
K	LYS457
I	LYS457

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
C	LYS476
E	LYS476
K	LYS476
I	LYS476

---