4BKX

The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex

Summary for 4BKX

DescriptorMETASTASIS-ASSOCIATED PROTEIN MTA1, HISTONE DEACETYLASE 1, ZINC ION, ... (6 entities in total)
Functional Keywordstranscription, inositol phosphate signalling, elm2-sant domain, hdac, hdac1, histone deacetylase, mta1
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform Short: Cytoplasm. Isoform Long: Nucleus Q13330
Nucleus Q13547
Total number of polymer chains2
Total molecular weight75727.02
Authors
Millard, C.J.,Watson, P.J.,Celardo, I.,Gordiyenko, Y.,Cowley, S.M.,Robinson, C.V.,Fairall, L.,Schwabe, J.W.R. (deposition date: 2013-04-30, release date: 2013-07-03, Last modification date: 2013-07-31)
Primary citation
Millard, C.J.,Watson, P.J.,Celardo, I.,Gordiyenko, Y.,Cowley, S.M.,Robinson, C.V.,Fairall, L.,Schwabe, J.W.R.
Class I Hdacs Share a Common Mechanism of Regulation by Inositol Phosphates.
Mol.Cell, 51:57-, 2013
PubMed: 23791785 (PDB entries with the same primary citation)
DOI: 10.1016/J.MOLCEL.2013.05.020
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26150.4%3.3%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4bkx.pdb1.gz [171.74 KB])
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