PDB: 125 件ウェブページステータス検索Chemie searchBIRD

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5MYK	Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with murine Abeta-pE3-18PEGb 分子名称: Amyloid beta A4 protein, Fab c#17 heavy chain, Fab c#17 light chain 著者 Parthier, C, Piechotta, A, Stubbs, M.T. 登録日 2017-01-26 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292, 2017
5MYX	Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18 分子名称: Fab c#24 heavy chain, Fab c#24 light chain, Pyroglutamate-Abeta pE3-18 著者 Parthier, C, Piechotta, A, Stubbs, M.T. 登録日 2017-01-30 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.492 Å) 主引用文献 Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292, 2017
5VZY	Crystal structure of crenezumab Fab in complex with Abeta 分子名称: Amyloid beta A4 protein, Crenezumab Fab heavy chain,Immunoglobulin gamma-1 heavy chain, Crenezumab Fab light chain,Immunoblobulin light chain 著者 Ultsch, M, Wang, W. 登録日 2017-05-29 公開日 2017-08-09 最終更新日 2017-09-13 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Structure of Crenezumab Complex with Abeta Shows Loss of beta-Hairpin. Sci Rep, 6, 2016
5OQV	Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM 分子名称: Amyloid beta A4 protein 著者 Gremer, L, Schoelzel, D, Schenk, C, Reinartz, E, Labahn, J, Ravelli, R, Tusche, M, Lopez-Iglesias, C, Hoyer, W, Heise, H, Willbold, D, Schroeder, G.F. 登録日 2017-08-14 公開日 2017-09-13 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Fibril structure of amyloid-beta (1-42) by cryo-electron microscopy. Science, 358, 2017
6NB9	Amyloid-Beta (20-34) with L-isoaspartate 23 分子名称: Amyloid-beta A4 protein 著者 Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S. 登録日 2018-12-06 公開日 2019-08-07 最終更新日 2022-09-07 実験手法 ELECTRON CRYSTALLOGRAPHY (1.05 Å) 主引用文献 Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun, 10, 2019
6IYC	Recognition of the Amyloid Precursor Protein by Human gamma-secretase 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhou, R, Yang, G, Guo, X, Zhou, Q, Lei, J, Shi, Y. 登録日 2018-12-14 公開日 2019-01-23 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Recognition of the amyloid precursor protein by human gamma-secretase. Science, 363, 2019
6OC9	S8 phosphorylated beta amyloid 40 fibrils 分子名称: Amyloid-beta precursor protein, PHOSPHONATE 著者 Qiang, W, Hu, Z.W. 登録日 2019-03-22 公開日 2019-06-05 最終更新日 2024-05-01 実験手法 SOLID-STATE NMR 主引用文献 Molecular structure of an N-terminal phosphorylated beta-amyloid fibril. Proc.Natl.Acad.Sci.USA, 116, 2019
6OIZ	Amyloid-Beta (20-34) wild type 分子名称: Amyloid beta A4 protein 著者 Sawaya, M.R, Warmack, R.A, Zee, C.T, Gonen, T, Clarke, S.G, Eisenberg, D.S. 登録日 2019-04-10 公開日 2019-08-07 最終更新日 2024-05-15 実験手法 ELECTRON CRYSTALLOGRAPHY (1.1 Å) 主引用文献 Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun, 10, 2019
6RHY	Structure of pore-forming amyloid-beta tetramers 分子名称: Amyloid beta A4 protein 著者 Bardiaux, B, Ciudad, S, Carulla, N. 登録日 2019-04-23 公開日 2019-09-25 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 A beta (1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage. Nat Commun, 11, 2020
6SHS	Abeta fibril (Morphology I) 分子名称: Amyloid-beta precursor protein 著者 Kollmer, M, Fandrich, M. 登録日 2019-08-08 公開日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Cryo-EM structure and polymorphism of A beta amyloid fibrils purified from Alzheimer's brain tissue. Nat Commun, 10, 2019
6SZF	Solution structure of the amyloid beta-peptide (1-42) 分子名称: Amyloid-beta precursor protein 著者 Grimaldi, M, Santoro, A, Stillitano, I, Buonocore, M, D'Ursi, A.M. 登録日 2019-10-02 公開日 2020-10-14 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Exploring the Early Stages of the Amyloid A beta (1-42) Peptide Aggregation Process: An NMR Study. Pharmaceuticals, 14, 2021
6TI6	Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils 分子名称: Amyloid-beta precursor protein 著者 Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. 登録日 2019-11-21 公開日 2020-07-22 最終更新日 2023-06-14 実験手法 SOLID-STATE NMR 主引用文献 Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils. Chem.Commun.(Camb.), 56, 2020
6TI7	Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils 分子名称: Amyloid-beta precursor protein 著者 Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. 登録日 2019-11-21 公開日 2020-07-22 最終更新日 2023-06-14 実験手法 SOLID-STATE NMR 主引用文献 Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils. Chem.Commun.(Camb.), 56, 2020
6TI5	A New Structural Model of Abeta(1-40) Fibrils 分子名称: Amyloid-beta precursor protein 著者 Bertini, I, Gonnelli, L, Luchinat, C, Mao, J, Nesi, A. 登録日 2019-11-21 公開日 2020-07-22 最終更新日 2023-06-14 実験手法 SOLID-STATE NMR 主引用文献 Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils. Chem.Commun.(Camb.), 56, 2020
6W0O	Amyloid-beta(1-40) fibril derived from Alzheimer's disease cortical tissue 分子名称: Amyloid-beta precursor protein 著者 Ghosh, U, Thurber, K.R, Tycko, R. 登録日 2020-03-02 公開日 2021-01-13 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.77 Å), SOLID-STATE NMR 主引用文献 Molecular structure of a prevalent amyloid-beta fibril polymorph from Alzheimer's disease brain tissue. Proc.Natl.Acad.Sci.USA, 118, 2021
6YHF	Solution NMR Structure of APP TMD 分子名称: Amyloid-beta precursor protein 著者 Silber, M, Muhle-Goll, C. 登録日 2020-03-29 公開日 2020-12-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
6YHO	Solution NMR Structure of APP G38P mutant TM 分子名称: Amyloid-beta precursor protein G38P mutant 著者 Silber, M, Muhle-Goll, C. 登録日 2020-03-30 公開日 2020-12-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
6YHP	Solution NMR Structure of APP V44M mutant TMD 分子名称: Amyloid-beta precursor protein V44M mutant 著者 Silber, M, Muhle-Goll, C. 登録日 2020-03-30 公開日 2020-12-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
6YHI	Solution NMR Structure of APP G38L mutant TMD 分子名称: Amyloid-beta precursor protein G38L mutant 著者 Silber, M, Muhle-Goll, C. 登録日 2020-03-30 公開日 2020-12-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
6YHX	Solution NMR Structure of APP I45T mutant TMD 分子名称: Amyloid-beta precursor protein I45T mutant 著者 Silber, M, Muhle-Goll, C. 登録日 2020-03-31 公開日 2020-12-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
6WXM	X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 16-36 分子名称: Amyloid-beta protein, HEXANE-1,6-DIOL 著者 Kreutzer, A.G, Nowick, J.S. 登録日 2020-05-11 公開日 2020-07-08 最終更新日 2020-08-26 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 X-ray Crystallography Reveals Parallel and Antiparallel beta-Sheet Dimers of a beta-Hairpin Derived from A beta16-36that Assemble to Form Different Tetramers. Acs Chem Neurosci, 11, 2020
6XOV	CryoEM structure of human presequence protease in partial closed state 1 分子名称: Amyloid-beta precursor protein, Presequence protease, mitochondrial 著者 Liang, W.G, Zhao, M, Tang, W. 登録日 2020-07-07 公開日 2021-07-07 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition. Nat Commun, 13, 2022
7JXO	Triangular trimer of beta-hairpins derived from Abeta17-36 with an F20Cha mutation 分子名称: Amyloid-beta 17-36 peptide 著者 Kreutzer, A.G, Haerianardakani, S, Nowick, J.S. 登録日 2020-08-27 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by beta-Hairpins Derived from A beta. J.Am.Chem.Soc., 142, 2020
7JXN	Beta hairpin derived from Abeta17-36 with an F20Cha mutation 分子名称: Amyloid-beta 17-36 peptide, CHLORIDE ION, SODIUM ION 著者 Kreutzer, A.G, Haerianardakani, S, Nowick, J.S. 登録日 2020-08-27 公開日 2020-12-09 最終更新日 2020-12-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by beta-Hairpins Derived from A beta. J.Am.Chem.Soc., 142, 2020
7B3K	Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55) 分子名称: D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein 著者 Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S. 登録日 2020-12-01 公開日 2021-01-13 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64, 2021

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