6RHY

Structure of pore-forming amyloid-beta tetramers

Summary for 6RHY

• Entry DOI: 10.2210/pdb6rhy/pdb
• NMR Information: BMRB: 34396
• Descriptor: Amyloid beta A4 protein (1 entity in total)
• Functional Keywords: amyloid, alzheimer's disease, membrane pore, oligomer, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 18080.35

Authors

Bardiaux, B.,Ciudad, S.,Carulla, N. (deposition date: 2019-04-23, release date: 2019-09-25, Last modification date: 2023-06-14)

• Primary citation: Ciudad, S.,Puig, E.,Botzanowski, T.,Meigooni, M.,Arango, A.S.,Do, J.,Mayzel, M.,Bayoumi, M.,Chaignepain, S.,Maglia, G.,Cianferani, S.,Orekhov, V.,Tajkhorshid, E.,Bardiaux, B.,Carulla, N.; A beta (1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage.; Nat Commun, 11:3014-3014, 2020; PubMed: 32541820; DOI: 10.1038/s41467-020-16566-1

Experimental method

SOLUTION NMR