6TI7

Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils

Summary for 6TI7

• Entry DOI: 10.2210/pdb6ti7/pdb
• Related: 6TI6
• NMR Information: BMRB: 34456
• Descriptor: Amyloid-beta precursor protein (2 entities in total)
• Functional Keywords: amyloid beta peptides alzheimer's disease solid-state nmr supramolecular assembly, protein fibril
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 16
• Total formula weight: 70847.51

Authors

Cerofolini, L.,Ravera, E.,Bologna, S.,Wiglenda, T.,Boddrich, A.,Purfurst, B.,Benilova, A.,Korsak, M.,Gallo, G.,Rizzo, D.,Gonnelli, L.,Fragai, M.,De Strooper, B.,Wanker, E.E.,Luchinat, C. (deposition date: 2019-11-21, release date: 2020-07-22, Last modification date: 2024-06-19)

Primary citation

Cerofolini, L.,Ravera, E.,Bologna, S.,Wiglenda, T.,Boddrich, A.,Purfurst, B.,Benilova, I.,Korsak, M.,Gallo, G.,Rizzo, D.,Gonnelli, L.,Fragai, M.,De Strooper, B.,Wanker, E.E.,Luchinat, C.
Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56:8830-8833, 2020

PubMed Abstract: Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(1-40) peptides are mixed in a non-stoichiometric ratio.

PubMed: 32749391
DOI: 10.1039/d0cc02463e

Experimental method

SOLID-STATE NMR