6YHX

Solution NMR Structure of APP I45T mutant TMD

Summary for 6YHX

• Entry DOI: 10.2210/pdb6yhx/pdb
• NMR Information: BMRB: 34510
• Descriptor: Amyloid-beta precursor protein I45T mutant (1 entity in total)
• Functional Keywords: app, gamma secretase, transmembrane, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 3058.87

Authors

Silber, M.,Muhle-Goll, C. (deposition date: 2020-03-31, release date: 2020-12-09, Last modification date: 2020-12-23)

• Primary citation: Silber, M.,Hitzenberger, M.,Zacharias, M.,Muhle-Goll, C.; Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.; Acs Chem Neurosci, 11:4426-4433, 2020; PubMed: 33232115; DOI: 10.1021/acschemneuro.0c00640

Experimental method

SOLUTION NMR