6BD4
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![BU of 6bd4 by Molmil](/molmil-images/mine/6bd4) | Crystal structure of human apo-Frizzled4 receptor | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Frizzled-4/Rubredoxin chimeric protein, OLEIC ACID, ... | Authors: | Yang, S, Wu, Y, Pu, M, Chen, Y, Dong, S, Guo, Y, Han, G.Y, Stevens, R.C, Zhao, S, Xu, F. | Deposit date: | 2017-10-21 | Release date: | 2018-08-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature, 560, 2018
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4JKV
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![BU of 4jkv by Molmil](/molmil-images/mine/4jkv) | Structure of the human smoothened 7TM receptor in complex with an antitumor agent | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-fluoro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wang, C, Wu, H, Katritch, V, Han, G.W, Huang, X, Liu, W, Siu, F.Y, Roth, B.L, Cherezov, V, Stevens, R.C, GPCR Network (GPCR) | Deposit date: | 2013-03-11 | Release date: | 2013-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structure of the human smoothened receptor bound to an antitumour agent. Nature, 497, 2013
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4QIN
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![BU of 4qin by Molmil](/molmil-images/mine/4qin) | Structure of the human smoothened receptor in complex with SAG1.5 | Descriptor: | 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide, Smoothened homolog/Soluble cytochrome b562 chimeric protein | Authors: | Wang, C, Wu, H, Evron, T, Vardy, E, Han, G.W, Huang, X.-P, Hufeisen, S.J, Mangano, T.J, Urban, D.J, Katritch, V, Cherezov, V, Caron, M.G, Roth, B.L, Stevens, R.C, GPCR Network (GPCR) | Deposit date: | 2014-05-31 | Release date: | 2014-07-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun, 5, 2014
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4QIM
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![BU of 4qim by Molmil](/molmil-images/mine/4qim) | Structure of the human smoothened receptor in complex with ANTA XV | Descriptor: | 2-{6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}propan-2-ol, Smoothened homolog/Soluble cytochrome b562 chimeric protein, ZINC ION | Authors: | Wang, C, Wu, H, Evron, T, Vardy, E, Han, G.W, Huang, X.-P, Hufeisen, S.J, Mangano, T.J, Urban, D.J, Katritch, V, Cherezov, V, Caron, M.G, Roth, B.L, Stevens, R.C, GPCR Network (GPCR) | Deposit date: | 2014-05-31 | Release date: | 2014-07-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun, 5, 2014
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6O3C
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![BU of 6o3c by Molmil](/molmil-images/mine/6o3c) | Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8 | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-4,7-difluoro-N-{[2-methoxy-5-(pyridin-4-yl)phenyl]methyl}-N-[trans-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide, ... | Authors: | Deshpande, I.S, Liang, J, Hedeen, D, Roberts, K.J, Zhang, Y, Ha, B, Latorraca, N.R, Faust, B, Dror, R.O, Beachy, P.A, Myers, B.R, Manglik, A. | Deposit date: | 2019-02-26 | Release date: | 2019-07-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature, 571, 2019
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4N4W
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![BU of 4n4w by Molmil](/molmil-images/mine/4n4w) | Structure of the human smoothened receptor in complex with SANT-1. | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine, Cytochrome b(562),Smoothened homolog, ... | Authors: | Wang, C, Wu, H, Han, G.W, Cherezov, V, Stevens, R.C, GPCR Network (GPCR) | Deposit date: | 2013-10-08 | Release date: | 2014-01-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun, 5, 2014
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5V56
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![BU of 5v56 by Molmil](/molmil-images/mine/5v56) | 2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN MONONUCLEOTIDE, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, ... | Authors: | Zhang, X, Zhao, F, Wu, Y, Yang, J, Han, G.W, Zhao, S, Ishchenko, A, Ye, L, Lin, X, Ding, K, Dharmarajan, V, Griffin, P.R, Gati, C, Nelson, G, Hunter, M.S, Hanson, M.A, Cherezov, V, Stevens, R.C, Tan, W, Tao, H, Xu, F. | Deposit date: | 2017-03-13 | Release date: | 2017-05-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun, 8, 2017
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7ZI0
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![BU of 7zi0 by Molmil](/molmil-images/mine/7zi0) | Structure of human Smoothened in complex with cholesterol and SAG | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, ... | Authors: | Byrne, E.F.X, Woolley, R.E, Ansell, B, Sansom, M.S.P, Newstead, S, Siebold, C. | Deposit date: | 2022-04-07 | Release date: | 2022-06-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Sci Adv, 8, 2022
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5V57
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![BU of 5v57 by Molmil](/molmil-images/mine/5v57) | 3.0A SYN structure of the multi-domain human smoothened receptor in complex with TC114 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FLAVIN MONONUCLEOTIDE, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, ... | Authors: | Zhang, X, Zhao, F, Wu, Y, Yang, J, Han, G.W, Zhao, S, Ishchenko, A, Ye, L, Lin, X, Ding, K, Dharmarajan, V, Griffin, P.R, Gati, C, Nelson, G, Hunter, M.S, Hanson, M.A, Cherezov, V, Stevens, R.C, Tan, W, Tao, H, Xu, F. | Deposit date: | 2017-03-13 | Release date: | 2017-05-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun, 8, 2017
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6XBM
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![BU of 6xbm by Molmil](/molmil-images/mine/6xbm) | Structure of human SMO-Gi complex with 24(S),25-EC | Descriptor: | 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Qi, X, Long, T, Li, X. | Deposit date: | 2020-06-06 | Release date: | 2020-09-30 | Last modified: | 2020-11-25 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
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8JHI
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![BU of 8jhi by Molmil](/molmil-images/mine/8jhi) | FZD3-Gs complex | Descriptor: | Frizzled-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, F, Zhang, Z. | Deposit date: | 2023-05-23 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell Discov, 10, 2024
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8JH7
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![BU of 8jh7 by Molmil](/molmil-images/mine/8jh7) | FZD6 in inactive state | Descriptor: | Frizzled-6,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | Authors: | Xu, F, Zhang, Z. | Deposit date: | 2023-05-22 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell Discov, 10, 2024
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5L7D
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![BU of 5l7d by Molmil](/molmil-images/mine/5l7d) | Structure of human Smoothened in complex with cholesterol | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, SODIUM ION, ... | Authors: | Byrne, E.F.X, Sircar, R, Miller, P.S, Hedger, G, Luchetti, G, Nachtergaele, S, Tully, M.D, Mydock-McGrane, L, Covey, D.F, Rambo, R.P, Sansom, M.S.P, Newstead, S, Rohatgi, R, Siebold, C. | Deposit date: | 2016-06-03 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of Smoothened regulation by its extracellular domains. Nature, 535, 2016
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4O9R
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![BU of 4o9r by Molmil](/molmil-images/mine/4o9r) | Human Smoothened Receptor structure in complex with cyclopamine | Descriptor: | Cyclopamine, Smoothened homolog/Soluble cytochrome b562 chimeric protein | Authors: | Wang, C, Weierstall, U, James, D, White, T.A, Wang, D, Liu, W, Spence, J.C.H, Doak, R.B, Nelson, G, Fromme, P, Fromme, R, Grotjohann, I, Kupitz, C, Zatsepin, N.A, Liu, H, Basu, S, Wacker, D, Han, G.W, Katritch, V, Boutet, S, Messerschmidt, M, Willams, G.J, Koglin, J.E, Seibert, M.M, Klinker, M, Gati, C, Shoeman, R.L, Barty, A, Chapman, H.N, Kirian, R.A, Beyerlein, K.R, Stevens, R.C, Li, D, Shah, S.T.A, Howe, N, Caffrey, M, Cherezov, V, GPCR Network (GPCR) | Deposit date: | 2014-01-02 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.204 Å) | Cite: | Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. Nat Commun, 5, 2014
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8YY8
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![BU of 8yy8 by Molmil](/molmil-images/mine/8yy8) | Fzd7 -Gs complex | Descriptor: | Frizzled-7, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Chen, B, Xu, L, Han, G.W, Xu, F. | Deposit date: | 2024-04-03 | Release date: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G s . Cell Res., 31, 2021
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6XBK
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![BU of 6xbk by Molmil](/molmil-images/mine/6xbk) | Structure of human SMO-G111C/I496C complex with Gi | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Qi, X, Long, T, Li, X. | Deposit date: | 2020-06-06 | Release date: | 2020-09-30 | Last modified: | 2020-11-25 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
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8QEO
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![BU of 8qeo by Molmil](/molmil-images/mine/8qeo) | |
8JHB
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![BU of 8jhb by Molmil](/molmil-images/mine/8jhb) | FZD6 Gs complex | Descriptor: | Frizzled-6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, F, Zhang, Z. | Deposit date: | 2023-05-23 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell Discov, 10, 2024
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8JHC
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![BU of 8jhc by Molmil](/molmil-images/mine/8jhc) | FZD3 in inactive state | Descriptor: | Frizzled-3,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | Authors: | Xu, F, Zhang, Z. | Deposit date: | 2023-05-23 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell Discov, 10, 2024
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5L7I
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![BU of 5l7i by Molmil](/molmil-images/mine/5l7i) | Structure of human Smoothened in complex with Vismodegib | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, SODIUM ION, ... | Authors: | Byrne, E.X.B, Sircar, R, Miller, P.S, Hedger, G, Luchetti, G, Nachtergaele, S, Tully, M.D, Mydock-McGrane, L, Covey, D.F, Rambo, R.F, Sansom, M.S.P, Newstead, S, Rohatgi, R, Siebold, C. | Deposit date: | 2016-06-03 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis of Smoothened regulation by its extracellular domains. Nature, 535, 2016
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8J9O
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![BU of 8j9o by Molmil](/molmil-images/mine/8j9o) | Cryo-EM structure of inactive FZD1 | Descriptor: | Frizzled-1,Soluble cytochrome b562, anti-BRIL Fab Heavy Chain, anti-BRIL Fab Light Chain, ... | Authors: | Lin, X, Xu, F. | Deposit date: | 2023-05-04 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell Discov, 10, 2024
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8J9N
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![BU of 8j9n by Molmil](/molmil-images/mine/8j9n) | Gq bound FZD1 in ligand-free state | Descriptor: | Frizzled-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Lin, X, Xu, F. | Deposit date: | 2023-05-04 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell Discov, 10, 2024
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6WW2
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![BU of 6ww2 by Molmil](/molmil-images/mine/6ww2) | Structure of human Frizzled5 by fiducial-assisted cryo-EM | Descriptor: | Frizzled-5,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | Authors: | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | Deposit date: | 2020-05-07 | Release date: | 2020-08-19 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. Elife, 9, 2020
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8CXO
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![BU of 8cxo by Molmil](/molmil-images/mine/8cxo) | Cryo-EM structure of the unliganded mSMO-PGS2 in a lipidic environment | Descriptor: | CHOLESTEROL, Smoothened homolog, GlgA glycogen synthase chimera | Authors: | Zhang, K, Wu, H, Hoppe, N, Manglik, A, Cheng, Y. | Deposit date: | 2022-05-22 | Release date: | 2022-08-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Nat Commun, 13, 2022
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6XBJ
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![BU of 6xbj by Molmil](/molmil-images/mine/6xbj) | Structure of human SMO-D384R complex with Gi | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Qi, X, Long, T, Li, X. | Deposit date: | 2020-06-06 | Release date: | 2020-09-30 | Last modified: | 2020-11-25 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
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