Structure of the human smoothened receptor in complex with SAG1.5

Summary for 4QIN

Related4O9R 4QIM
DescriptorSmoothened homolog/Soluble cytochrome b562 chimeric protein, 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide (3 entities in total)
Functional Keywordshuman smoothened receptor, agonist, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, signaling protein
Biological sourceHomo sapiens
Cellular locationMembrane ; Multi-pass membrane protein  Q99835
Total number of polymer chains1
Total molecular weight52921.24
Primary citation
Wang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C.
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Nat Commun, 5:4355-4355, 2014
PubMed: 25008467 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms5355
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.282606.5%6.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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