Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4QIM

Structure of the human smoothened receptor in complex with ANTA XV

Summary for 4QIM
Entry DOI10.2210/pdb4qim/pdb
Related4O9R 4QIN
DescriptorSmoothened homolog/Soluble cytochrome b562 chimeric protein, 2-{6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}propan-2-ol, ZINC ION, ... (4 entities in total)
Functional Keywordshuman smoothened receptor, antitumor agent, novel protein engineering, gpcr network, psi-biology, structural genomics, membrane protein, gpcr, membrane, signaling protein
Biological sourceHomo sapiens
More
Cellular locationMembrane ; Multi-pass membrane protein : Q99835
Total number of polymer chains1
Total formula weight52900.16
Authors
Primary citationWang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C.
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Nat Commun, 5:4355-4355, 2014
Cited by
PubMed: 25008467
DOI: 10.1038/ncomms5355
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.61 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon