4QIN

Structure of the human smoothened receptor in complex with SAG1.5

Summary for 4QIN

Entry DOI	10.2210/pdb4qin/pdb
Related	4O9R 4QIM
Descriptor	Smoothened homolog/Soluble cytochrome b562 chimeric protein, 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide (3 entities in total)
Functional Keywords	human smoothened receptor, agonist, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, signaling protein
Biological source	Homo sapiens More
Cellular location	Membrane ; Multi-pass membrane protein : Q99835
Total number of polymer chains	1
Total formula weight	52921.24
Authors	Wang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.-P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2014-05-31, release date: 2014-07-23, Last modification date: 2023-09-20)
Primary citation	Wang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun, 5:4355-4355, 2014 Cited by PubMed: 25008467 DOI: 10.1038/ncomms5355 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation